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- Title
Identification of mokB involved in monacolin K biosynthesis in Monascus pilosus.
- Authors
Sakai, Kanae; Kinoshita, Hiroshi; Nihira, Takuya
- Abstract
Monacolin K (MK), which is widely used as an antihypercholesterolemia medicine, is produced as a fungal secondary metabolite through the polyketide pathway. The MK biosynthetic gene cluster proposed for Monascus pilosus BCRC38072 was also identified in M. pilosus NBRC4480. The mokB gene, located at the end of the putative gene cluster and possibly encoding polyketide synthase, was disrupted. The mokB disruptant did not produce MK, but accumulated an intermediate that was confirmed to be monacolin J, indicating that mokB encodes the polyketide synthase responsible for the biosynthesis of side-chain diketide moiety.
- Subjects
DRUGS; METABOLITES; BIOSYNTHESIS; POLYKETIDES; ASPERGILLUS
- Publication
Biotechnology Letters, 2009, Vol 31, Issue 12, p1911
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-009-0093-3