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- Title
Prognostic roles of KL‐6 in disease severity and lung injury in COVID‐19 patients: A longitudinal retrospective analysis.
- Authors
Deng, Kai; Fan, Qinghong; Yang, Yanhong; Deng, Xizi; He, Ruiying; Tan, Yizhou; Lan, Yun; Deng, Xilong; Pan, Yuejun; Wang, Yaping; Guan, Yujuan; Liu, Huiyuan; Chen, Fengjuan; Mo, Xiaoneng; Tan, Xinghua; Luo, Chun; Wen, Xueliang; Liu, Ying; Liu, Jinxin; Zhang, Lieguang
- Abstract
To investigate the dynamic changes of Krebs von den Lungen‐6 (KL‐6) among patients with coronavirus disease 2019 (COVID‐19) and the role of KL‐6 as a noninvasive biomarker for predicting long‐term lung injury, the clinical information and laboratory tests of 166 COVID‐19 patients were collected, and a correlation analysis between KL‐6 and other parameters was conducted. There were 17 (10.2%, 17/166) severe/critical and 149 (89.8%, 149/166) mild COVID‐19 patients in our cohort. Serum KL‐6 was significantly higher in severe/critical COVID‐19 patients than in mild patients (median 898.0 vs. 451.2 U/ml, p <.001). KL‐6 was next confirmed to be a sensitive and specific biomarker for distinguishing mild and severe/critical patients and correlate to computed tomography lung lesions areas. Serum KL‐6 concentration during the follow‐up period (>100 days postonset) was well correlated to those concentrations within 10 days postonset (Pearson r =.867, p <.001), indicating the prognostic value of KL‐6 levels in predicting lung injury after discharge. Finally, elevated KL‐6 was found to be significantly correlated to coagulation disorders, and T cells subsets dysfunctions. In summary, serum KL‐6 is a biomarker for assessing COVID‐19 severity and predicting the prognosis of lung injury of discharged patients. Highlights: KL‐6 is a biomarker for assessing COVID‐19 severityKL‐6 predicts the prognosis of COVID‐19 patientsKL‐6 is associated with CT lung lesions areas.
- Subjects
COVID-19; LUNG injuries; COMPUTED tomography; PROGNOSIS; LUNG diseases
- Publication
Journal of Medical Virology, 2021, Vol 93, Issue 4, p2505
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.26793