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- Title
Development of compression-controlled low-level laser probe system: towards clinical application.
- Authors
Changmin Yeo; Taeyoon Son; Junghwan Park; Young-Heum Lee; Kiwoon Kwon; J. Stuart Nelson; Byungjo Jung; Yeo, Changmin; Son, Taeyoon; Park, Junghwan; Lee, Young-Heum; Kwon, Kiwoon; Nelson, J Stuart; Jung, Byungjo
- Abstract
Various physico-chemical tissue optical clearing (TOC) methods have been suggested to maximize photon density in tissue. In order to enhance photon density, a compression-controlled low-level laser probe (CCLLP) system was developed by utilizing the principle of mechanical tissue compression. Negative compression (NC) was applied to the laser probes built in various diameters and simultaneously the laser was irradiated into ex-vivo porcine skin samples. Laser photon density (LPD) was evaluated as a function of NC and probe diameter by analyzing 2D diffusion images of the laser exposures. The CCLLP system resulted in a concentrated laser beam profile, which means enhancement of the LPD. As indicators of LPD, the laser peak intensity increased and the full width at half maximum (FWHM) decreased as a function of NC. The peak intensity at –30 kPa increased 2.74, 3.22, and 3.64 fold at laser probe diameters of 20, 30, and 40 mm, respectively. In addition, sample temperature was measured with a thermal camera and increased 0.4 K at –30 kPa after 60 s of laser irradiation as a result of enhanced LPD. The CCLLP system effectively demonstrated enhancement of the LPD in tissue and potentially its clinical feasibility.
- Subjects
INDUSTRIAL lasers; LASER beams; SEMICONDUCTOR doping; PHOTON detectors; NONLINEAR optics; ANIMAL experimentation; COMPARATIVE studies; HEAT; KINEMATICS; MATHEMATICAL models; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; SKIN; SKIN physiology; SWINE; THEORY; PRODUCT design; EVALUATION research; COMPRESSIVE strength; IN vitro studies
- Publication
Lasers in Medical Science, 2010, Vol 25, Issue 5, p699
- ISSN
0268-8921
- Publication type
journal article
- DOI
10.1007/s10103-010-0779-8