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- Title
Characterisation of Expression of mDMAHP, a Homeodomain-Encoding Gene at the Murine DM Locus.
- Authors
Heath, Stephanie K.; Carne, Simon; Hoyle, Christine; Johnson, Keith J.; Wells, Dominic J.
- Abstract
We examined the expression of the murine homologue of myotonic dystrophy associated homeodomain protein (mDMAHP) using two different strategies. The first approach, RT-PCR, detected spliced transcripts in a wide range of embryonic and adult tissues, in a pattern overlapping substantially with the expression of mDMPK. A second approach, the generation of transgenic mice expressing the lacZ reporter gene from a 4.3 kb promoter fragment, also demonstrated expression in a range of tissues with potential links to the phenotype in myotonic dystrophy. We conclude that murine DMAHP has a similar pattern of expression to human DMAHP and will serve as a useful model for functional studies of this gene, although species differences, such as the reduced CpG island (1.8 kb compared with 3.5 kb) must be carefully considered.
- Publication
Human Molecular Genetics, 1997, Vol 6, Issue 5, p651
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/6.5.651