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Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells.
Published in:
Stem Cells Translational Medicine, 2017, v. 6, n. 8, p. 1751, doi. 10.1002/sctm.12187
By:
- Heslop, James A.;
- Kia, Richard;
- Pridgeon, Christopher S.;
- Sison-Young, Rowena L.;
- Liloglou, Triantafillos;
- Elmasry, Mohamed;
- Fenwick, Stephen W.;
- Mills, John S.;
- Kitteringham, Neil R.;
- Goldring, Chris E.;
- Park, B. Kevin
Publication type:
Article
Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells.
Published in:
Stem Cells Translational Medicine, 2017, v. 6, n. 5, p. 1321, doi. 10.1002/sctm.16-0029
By:
- Heslop, James A.;
- Kia, Richard;
- Pridgeon, Christopher S.;
- Sison-Young, Rowena L.;
- Liloglou, Triantafillos;
- Elmasry, Mohamed;
- Fenwick, Stephen W.;
- Mills, John S.;
- Kitteringham, Neil R.;
- Goldring, Chris E.;
- Park, Bong K.
Publication type:
Article
Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue‐engineered skin equivalents.
Published in:
Experimental Dermatology, 2018, v. 27, n. 5, p. 473, doi. 10.1111/exd.13483
By:
- Smith, Sarah A.;
- Colley, Helen E.;
- Sharma, Parveen;
- Slowik, Klaudia M.;
- Sison‐young, Rowena;
- Sneddon, Andrew;
- Webb, Steven D.;
- Murdoch, Craig
Publication type:
Article
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.
Published in:
Scientific Reports, 2016, p. 25187, doi. 10.1038/srep25187
By:
- Bell, Catherine C.;
- Hendriks, Delilah F. G.;
- Moro, Sabrina M. L.;
- Ellis, Ewa;
- Walsh, Joanne;
- Renblom, Anna;
- Fredriksson Puigvert, Lisa;
- Dankers, Anita C. A.;
- Jacobs, Frank;
- Snoeys, Jan;
- Sison-Young, Rowena L.;
- Jenkins, Rosalind E.;
- Nordling, Åsa;
- Mkrtchian, Souren;
- Park, B. Kevin;
- Kitteringham, Neil R.;
- Goldring, Christopher E. P.;
- Lauschke, Volker M.;
- Ingelman-Sundberg, Magnus
Publication type:
Article
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
Published in:
NPJ Systems Biology & Applications, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1038/s41540-018-0058-z
By:
- Oppelt, Angela;
- Kaschek, Daniel;
- Huppelschoten, Suzanna;
- Sison-Young, Rowena;
- Zhang, Fang;
- Buck-Wiese, Marie;
- Herrmann, Franziska;
- Malkusch, Sebastian;
- Krüger, Carmen L.;
- Meub, Mara;
- Merkt, Benjamin;
- Zimmermann, Lea;
- Schofield, Amy;
- Jones, Robert P.;
- Malik, Hassan;
- Schilling, Marcel;
- Heilemann, Mike;
- van de Water, Bob;
- Goldring, Christopher E.;
- Park, B. Kevin
Publication type:
Article
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.
Published in:
Archives of Toxicology, 2018, v. 92, n. 2, p. 557, doi. 10.1007/s00204-018-2152-9
By:
- Pridgeon, Chris S.;
- Schlott, Constanze;
- Wong, Min Wei;
- Heringa, Minne B.;
- Heckel, Tobias;
- Leedale, Joe;
- Launay, Laurence;
- Gryshkova, Vitalina;
- Przyborski, Stefan;
- Bearon, Rachel N.;
- Wilkinson, Emma L.;
- Ansari, Tahera;
- Greenman, John;
- Hendriks, Delilah F. G.;
- Gibbs, Sue;
- Sidaway, James;
- Sison-Young, Rowena L.;
- Walker, Paul;
- Cross, Mike J.;
- Park, B. Kevin
Publication type:
Article
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Published in:
Archives of Toxicology, 2017, v. 91, n. 3, p. 1385, doi. 10.1007/s00204-016-1745-4
By:
- Sison-Young, Rowena;
- Lauschke, Volker;
- Johann, Esther;
- Alexandre, Eliane;
- Antherieu, Sébastien;
- Aerts, Hélène;
- Gerets, Helga;
- Labbe, Gilles;
- Hoët, Delphine;
- Dorau, Martina;
- Schofield, Christopher;
- Lovatt, Cerys;
- Holder, Julie;
- Stahl, Simone;
- Richert, Lysiane;
- Kitteringham, Neil;
- Jones, Robert;
- Elmasry, Mohamed;
- Weaver, Richard;
- Hewitt, Philip G.
Publication type:
Article
Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.
Published in:
Archives of Toxicology, 2017, v. 91, n. 1, p. 439, doi. 10.1007/s00204-016-1694-y
By:
- Heslop, James;
- Rowe, Cliff;
- Walsh, Joanne;
- Sison-Young, Rowena;
- Jenkins, Roz;
- Kamalian, Laleh;
- Kia, Richard;
- Hay, David;
- Jones, Robert;
- Malik, Hassan;
- Fenwick, Stephen;
- Chadwick, Amy;
- Mills, John;
- Kitteringham, Neil;
- Goldring, Chris;
- Kevin Park, B.
Publication type:
Article
A systems approach reveals species differences in hepatic stress response capacity.
Published in:
Toxicological Sciences, 2023, v. 196, n. 1, p. 112, doi. 10.1093/toxsci/kfad085
By:
- Russomanno, Giusy;
- Sison-Young, Rowena;
- Livoti, Lucia A;
- Coghlan, Hannah;
- Jenkins, Rosalind E;
- Kunnen, Steven J;
- Fisher, Ciarán P;
- Reddyhoff, Dennis;
- Gardner, Iain;
- Rehman, Adeeb H;
- Fenwick, Stephen W;
- Jones, Andrew R;
- Conchard, Guy Vermeil De;
- Simonin, Gilles;
- Bertheux, Helene;
- Weaver, Richard J;
- Johnson, Robert L;
- Liguori, Michael J;
- Clausznitzer, Diana;
- Stevens, James L
Publication type:
Article
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.
Published in:
Toxicological Sciences, 2023, v. 192, n. 1, p. 106, doi. 10.1093/toxsci/kfad015
By:
- Ali, Serat-E;
- Waddington, James C;
- Lister, Adam;
- Sison-Young, Rowena;
- Jones, Robert P;
- Rehman, Adeeb H;
- Goldring, Chris E P;
- Naisbitt, Dean J;
- Meng, Xiaoli
Publication type:
Article
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.
Published in:
Toxicological Sciences, 2018, v. 162, n. 2, p. 655, doi. 10.1093/toxsci/kfx289
By:
- Bell, Catherine C;
- Dankers, Anita C A;
- Lauschke, Volker M;
- Sison-Young, Rowena;
- Jenkins, Roz;
- Rowe, Cliff;
- Goldring, Chris E;
- Park, Kevin;
- Regan, Sophie L;
- Walker, Tracy
Publication type:
Article
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.
Published in:
Toxicological Sciences, 2015, v. 147, n. 2, p. 412, doi. 10.1093/toxsci/kfv136
By:
- Sison-Young, Rowena L. C.;
- Mitsa, Dimitra;
- Jenkins, Rosalind E.;
- Mottram, David;
- Alexandre, Eliane;
- Richert, Lysiane;
- Aerts, Hélène;
- Weaver, Richard J.;
- Jones, Robert P.;
- Johann, Esther;
- Hewitt, Philip G.;
- Ingelman-Sundberg, Magnus;
- Goldring, Christopher E. P.;
- Kitteringham, Neil R.;
- Park, B. Kevin
Publication type:
Article
MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity.
Published in:
Toxicological Sciences, 2015, v. 144, n. 1, p. 173, doi. 10.1093/toxsci/kfu269
By:
- Kia, Richard;
- Kelly, Lorna;
- Sison-Young, Rowena L. C.;
- Zhang, Fang;
- Pridgeon, Chris S.;
- Heslop, James A.;
- Metcalfe, Pete;
- Kitteringham, Neil R.;
- Baxter, Melissa;
- Harrison, Sean;
- Hanley, Neil A.;
- Burke, Zoë D.;
- Storm, Mike P.;
- Welham, Melanie J.;
- Tosh, David;
- Küppers-Munther, Barbara;
- Edsbagge, Josefina;
- Starkey Lewis, Philip J.;
- Bonner, Frank;
- Harpur, Ernie
Publication type:
Article

Found: 13