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- Title
Synthesis and antituberculosis activity of derivatives of the diterpenoid isosteviol with azine, hydrazide, and hydrazone moieties.
- Authors
Garifullin, B. F.; Strobykina, I. Yu.; Mordovskoi, G. G.; Mironov, V. F.; Kataev, V. E.
- Abstract
Derivatives of the diterpenoid isosteviol (16-oxo- ent-beyeran-19-oic acid) with azine, hydrazone, and hydrazide moieties were synthesized. They exhibited high tuberculostatic activity in vitro against the strain Mycobacterium tuberculosis HR (minimum inhibiting concentration in the range 6.3-1.7 μg/mL).
- Subjects
ANTITUBERCULAR agents; MYCOBACTERIUM tuberculosis; TUBERCULOSIS treatment; HYDRAZONES; DITERPENES; ADIPIC acid
- Publication
Chemistry of Natural Compounds, 2011, Vol 47, Issue 1, p55
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-011-9829-0