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- Title
An improved and scale-up synthesis of 6-hydroxybenzofuran.
- Authors
Song, Shu-Yong; Lu, He-Lin; Wang, Gui-Fei; Yang, Yi-Qiu; Huang, Yun-Sheng
- Abstract
An optimized process for the preparation of 6-hydroxybenzofuran is described. This process consists of three steps: the reaction of 2-hydroxy-4-methoxybenzaldehyde with chloroacetic acid, the formation of the 6-methoxybenzofuran in acetic anhydride, and the demethylation with sodium 1-dodecanethiolate to afford the desired product. The entire process is safe, cost effective, environmentally benign, and scalable. A production scale of over 2.6 kg product was achieved in good overall yield.
- Subjects
CHEMICAL synthesis; HETEROCYCLIC compound derivatives; BENZOFURAN; ACETIC anhydride; CHLOROACETIC acids; DEMETHYLATION
- Publication
Research on Chemical Intermediates, 2016, Vol 42, Issue 5, p4433
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-015-2288-7