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- Title
Tumorigenesis: the origins of glioma.
- Authors
Alderton, Gemma K.
- Abstract
The article discusses a study on the cell of origin for glioma that is caused by inactivating mutations in neurofibromatosis 1 (Nf1) and Trp53. The researchers examined neural stem cells (NSC)-derived cell lineages including astrocytes, oligodendrocyte precursor cells (OPCs) and oligodendrocytes during tumorigenesis to investigate the glioma cell of origin. The study revealed that OPCs are the cell of origin for glioma that is associated with mutations in Nf1.
- Subjects
GLIOMAS; NEUROFIBROMATOSIS; ONCOGENES; CANCER genetics; NERVOUS system tumors; TUMOR growth; CARCINOGENESIS; GENETICS
- Publication
Nature Reviews Cancer, 2011, Vol 11, Issue 9, p627
- ISSN
1474-175X
- Publication type
journal article
- DOI
10.1038/nrc3129