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- Title
Emerging functions of the unfolded protein response in immunity.
- Authors
Janssens, Sophie; Pulendran, Bali; Lambrecht, Bart N
- Abstract
The unfolded protein response (UPR) has traditionally been viewed as an adaptive response triggered by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) and aimed at restoring ER function. The UPR can also be an anticipatory response that is activated well before the disruption of protein homeostasis. UPR signaling intersects at many levels with the innate and adaptive immune responses. In some types of cells of the immune system, such as dendritic cells (DCs) and B cells, particular sensors that detect the UPR seem to be constitutively active in the absence of induction of the traditional UPR gene program and are necessary for antigen presentation and immunoglobulin synthesis. The UPR also influences signaling via Toll-like receptors (TLRs) and activation of the transcription factor NF-κB, and some pathogens subvert the UPR. This Review summarizes these emerging noncanonical functions of the UPR in immunity.
- Subjects
DENATURATION of proteins; ENDOPLASMIC reticulum; CELLULAR signal transduction; DENDRITIC cells; ANTIGEN presentation; TOLL-like receptors; TRANSCRIPTION factors; NATURAL immunity
- Publication
Nature Immunology, 2014, Vol 15, Issue 10, p910
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.2991