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- Title
Acquired severe aplastic anemia treated with antithymocyte globulin and cyclosporine: An experience of regional cancer center, Western India.
- Authors
Patel, Ankit B.; Panchal, Harsha P.; Anand, Asha S.; Patel, Apurva A.; Parikh, Sonia P.; Shah, Sandip A.
- Abstract
Severe aplastic anemia (SAA) is a serious bone marrow disease that needs a comprehensive and service-intense treatment with either bone marrow transplantation (BMT) or immunosuppressive therapy (IST); both are difficult to optimally offer in resources-limited countries. Here, we report the outcome of IST using horse Antithymocyte globulin (ATG) in 18 (7 children; 11 adults) patients with SAA referred to our center in west India. Only 18 patients out of 102 diagnosed as AA in 2 years could receive IST, largely due to costs restraints. Although CR was seen in 30% in adults and 33% in pediatric cases, but overall 50% cases were able to enjoy transfusion-independence, requiring no further treatment. Treatment related mortality occurred in 6.2%, relapse in 6.2% and 6.2% had clonal evolution. This makes IST a valuable option for managing SAA in absence of bone marrow transplantation.
- Publication
Journal of Applied Hematology, 2015, Vol 6, Issue 2, p53
- ISSN
1658-5127
- Publication type
Article
- DOI
10.4103/1658-5127.160198