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- Title
Mesenchymal Stem Cell-Based Therapies in the Post-Acute Neurological COVID Syndrome: Current Landscape and Opportunities.
- Authors
León-Moreno, Lilia Carolina; Reza-Zaldívar, Edwin Estefan; Hernández-Sapiéns, Mercedes Azucena; Villafaña-Estarrón, Erika; García-Martin, Marina; Ojeda-Hernández, Doddy Denise; Matias-Guiu, Jordi A.; Gomez-Pinedo, Ulises; Matias-Guiu, Jorge; Canales-Aguirre, Alejandro Arturo
- Abstract
One of the main concerns related to SARS-CoV-2 infection is the symptoms that could be developed by survivors, known as long COVID, a syndrome characterized by persistent symptoms beyond the acute phase of the infection. This syndrome has emerged as a complex and debilitating condition with a diverse range of manifestations affecting multiple organ systems. It is increasingly recognized for affecting the Central Nervous System, in which one of the most prevalent manifestations is cognitive impairment. The search for effective therapeutic interventions has led to growing interest in Mesenchymal Stem Cell (MSC)-based therapies due to their immunomodulatory, anti-inflammatory, and tissue regenerative properties. This review provides a comprehensive analysis of the current understanding and potential applications of MSC-based interventions in the context of post-acute neurological COVID-19 syndrome, exploring the underlying mechanisms by which MSCs exert their effects on neuroinflammation, neuroprotection, and neural tissue repair. Moreover, we discuss the challenges and considerations specific to employing MSC-based therapies, including optimal delivery methods, and functional treatment enhancements.
- Subjects
POST-acute COVID-19 syndrome; MESENCHYMAL stem cells; CENTRAL nervous system; NERVE tissue; COGNITION disorders
- Publication
Biomolecules (2218-273X), 2024, Vol 14, Issue 1, p8
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom14010008