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- Title
Systemic Biomarkers and Unique Pathways in Different Phenotypes of Heart Failure with Preserved Ejection Fraction.
- Authors
Chen, Hao; Tesic, Milorad; Nikolic, Valentina N.; Pavlovic, Milan; Vucic, Rada M.; Spasic, Ana; Jovanovic, Hristina; Jovanovic, Ivana; Town, Stephanie E. L.; Padula, Matthew P.; McClements, Lana
- Abstract
Heart failure with preserved ejection fraction (HFpEF) accounts for around 50% of all heart failure cases. It is a heterogeneous condition with poorly understood pathogenesis. Here, we aimed to identify unique pathogenic mechanisms in acute and chronic HFpEF and hypertrophic cardiomyopathy (HCM). We performed unbiased, comprehensive proteomic analyses of plasma samples from gender- and BMI-matched patients with acute HFpEF (n = 8), chronic HFpEF (n = 9) and HCM (n = 14) using liquid chromatography–mass spectrometry. Distinct molecular signatures were observed in different HFpEF forms. Clusters of biomarkers differentially abundant between HFpEF forms were predominantly associated with microvascular inflammation. New candidate protein markers were also identified, including leucine-rich alpha-2-glycoprotein 1 (LRG1), serum amyloid A1 (SAA1) and inter-alpha-trypsin inhibitor heavy chain 3 (ITIH3). Our study is the first to apply systematic, quantitative proteomic screening of plasma samples from patients with different subtypes of HFpEF and identify candidate biomarkers for improved management of acute and chronic HFpEF and HCM.
- Subjects
VENTRICULAR ejection fraction; HEART failure; HYPERTROPHIC cardiomyopathy; BIOMARKERS; PHENOTYPES; LIQUID chromatography-mass spectrometry; TIME-of-flight mass spectrometry
- Publication
Biomolecules (2218-273X), 2022, Vol 12, Issue 10, pN.PAG
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom12101419