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- Title
Long‐standing multiple system atrophy‐Parkinsonism with limbic and FTLD‐type α‐synuclein pathology.
- Authors
Coughlin, David G.; Dryden, Ian; Goodwill, Vanessa S.; Pizzo, Donald P.; Wright, Brenton; Lessig, Stephanie; Galasko, Douglas; MacKenzie, Ian R.; Hiniker, Annie
- Abstract
(C) Mid-sagittal view of left hemibrain exhibiting olivopontocerebellar atrophy, medial frontal lobe atrophy and cingulate gyrus atrophy. Microscopically, there were GCIs, NCIs and NNIs pathognomonic for MSA with a limbic predominance of -synuclein-positive pathology that included Pick body-like, NFT-like and ring-shaped -synuclein positive NCIs in the hippocampus [1]. Keywords: Gallyas; multiple system atrophy; -synuclein EN Gallyas multiple system atrophy -synuclein 1 5 5 03/11/22 20220401 NES 220401 INTRODUCTION Multiple system atrophy (MSA) is a sporadic neurodegenerative disease clinically marked by autonomic failure and variable degrees of Parkinsonism and cerebellar ataxias. Four different -synuclein antibodies highlighted only scant -synuclein-positive pathology; however, Gallyas and Campbell-Switzer silver stains identified additional GCIs most prominent in subcortical white matter.
- Subjects
ALPHA-synuclein; LIMBIC system; ENTORHINAL cortex; FRONTAL lobe; PATHOLOGY; FRONTOTEMPORAL lobar degeneration; PROGRESSIVE supranuclear palsy
- Publication
Neuropathology & Applied Neurobiology, 2022, Vol 48, Issue 3, p1
- ISSN
0305-1846
- Publication type
Article
- DOI
10.1111/nan.12783