We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Integrins as developmental switches.
- Authors
Watkins, Trent A.; Barres, Ben A.
- Abstract
Neuregulin (NRG) is a crucial regulator of oligodendrocyte development, strongly promoting both the proliferation of oligodendrocyte precursor cells and the survival and maturation of oligodendrocytes. How can the same growth factor mediate such different effects? New work in this issue of Nature Cell Biology implicates an integrin-mediated switch in signalling that results in the loss of the proliferative response and the enhancement of survival and maturation.
- Subjects
INTEGRINS; CYTOLOGY; GROWTH factors
- Publication
Nature Cell Biology, 2002, Vol 4, Issue 11, pE253
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1102-e253