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- Title
Identification of genes potentially involved in disease transformation of CML.
- Authors
Janssen, J. J. W. M.; Klaver, S. M.; Waisfisz, Q.; Pasterkamp, G.; de Kleijn, D. P. V.; Schuurhuis, G. J.; Ossenkoppele, G. J.
- Abstract
In patients with chronic myeloid leukemia (CML) who do not reach a (near) complete cytogenetic response, the disease progresses over several years from an indolent, chronic phase into a rapidly fatal blast crisis. Events that are responsible for this transformation process are largely unknown. To identify changes in gene expression that occurred during the course of the disease, we performed cDNA subtraction on sequentially stored peripheral blood mononuclear cell pellets, collected throughout the course of disease of a single CML patient. In total, 32 differentially expressed sequences were identified, of which 27 corresponded to known genes. On quantitative PCR, eight of these genes, YWHAZ, GAS2, IL8, IL6, PBEF1, CCL4, SAT and MMRN, showed comparable differential expression in additional CML patient samples. This set of genes can be considered as a starting point for further research on causes of disease transformation in CML and may lead to new targets in the treatment of resistant CML.Leukemia (2005) 19, 998-1004. doi:10.1038/sj.leu.2403735 Published online 7 April 2005
- Subjects
CHRONIC myeloid leukemia; BLOOD cells; MYELOID leukemia; GENE expression; GENETIC regulation; LEUKEMIA
- Publication
Leukemia (08876924), 2005, Vol 19, Issue 6, p998
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/sj.leu.2403735