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- Title
Abdominal obesity and dsyglycemia are risk factors for liver fibrosis progression in NAFLD subjects: A population-based study.
- Authors
Julian, Maria Teresa; Ballesta, Silvia; Pera, Guillem; Perez-Montes de Oca, Alejandra; Soldevila, Berta; Caballería, Llorenç; Morillas, Rosa; Exposito, Carmen; Martínez-Escude, Alba; Puig-Domingo, Manel; Franch-Nadal, Josep; Toran, Pere; Cusi, Kenneth; Julve, Josep; Mauricio, Dídac; Alonso, Nuria
- Abstract
Objective: To investigate longitudinal changes in the liver stiffness measurement (LSM) in the general adult population without known liver disease and to describe its association with metabolic risk factors, with a special focus on subjects with non-alcoholic fatty liver disease (NAFLD) and dysglycemia. Material and Methods: A longitudinal adult population-based cohort study was conducted in Catalonia. LSM was measured by transient elastography (TE) at baseline and follow-up (median: 4.2 years). Subgroup with NAFLD and dysglycemia were analyzed. Moderate-to-advanced liver fibrosis was defined as LSM ≥8.0 kPa and LSM ≥9.2 kPa respectively. Results: Among 1.478 subjects evaluated, the cumulative incidence of LSM ≥8.0 kPa and ≥9.2 kPa at follow-up was 2.8% and 1.9%, respectively. This incidence was higher in NAFLD (7.1% for LSM ≥8.0 kPa and 5% for LSM ≥9.2 kPa) and dysglycemia (6.2% for LSM ≥8.0 kPa and 4.7% for LSM ≥9.2 kPa) subgroups. In the global cohort, the multivariate analyses showed that dysglycemia, abdominal obesity and atherogenic dyslipidemia were significantly associated with progression to moderate-to-advanced liver fibrosis. Female sex was negatively associated. In subjects with NAFLD, abdominal obesity and dysglycemia were associated with changes in LSM to ≥8.0 kPa and ≥9.2 kPa at follow-up. A decline in LSM value to <8 kPa was observed in 64% of those subjects with a baseline LSM ≥8.0 kPa. Conclusions: In this population study, the presence of abdominal obesity and dysglycemia were the main risk metabolic factors associated with moderate-to-advanced liver fibrosis development over time in general populations as well as in subjects with NAFLD.
- Subjects
CATALONIA (Spain); HEPATIC fibrosis; NON-alcoholic fatty liver disease; OBESITY; LIVER diseases; FATTY liver
- Publication
Frontiers in Endocrinology, 2023, Vol 13, p01
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2022.1051958