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- Title
MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia.
- Authors
Evans, Brian C.; Hocking, Kyle M.; Osgood, Michael J.; Voskresensky, Igor; Dmowska, Julia; Kilchrist, Kameron V.; Brophy, Colleen M.; Duvall, Craig L.
- Abstract
The article focuses findings of a study on role of MK2 inhibitory peptide delivered in nanopolyplexes in preventing vascular graft intimal hyperplasia. It states a nanopolyplex (NP) approach that efficiently delivers a mitogen-activated protein kinase (MAPK)–activated protein (MAPKAP) kinase 2 inhibitory peptide (MK2i) to graft tissue, and mentions that MK2i-NPs blocked inflammatory and migratory signaling. It infers that MK2 inhibitors can be promising strategy for preventing graft failure.
- Subjects
HYPERPLASIA; ENZYME inhibitors; PEPTIDES; MITOGEN-activated protein kinase genetics; DRUG delivery systems; PREVENTION; THERAPEUTICS
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 291, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaa4549