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- Title
Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients.
- Authors
Farouk, Nehal; Ashry, Walaa Mohamed Omar; EL-Hagrasy, Hanan A; Mohamed, Eman F; Eltrawy, Heba H; El-Nasser, Asmaa M; Shipl, Walaa; El Attar, Shahinaz; Sakr, Lobna Kh; Wahab, Maisa A Abdel; Abdelsalam, Eman M; Sharaf, Fawzia A; Ahmad, Inass Hassan
- Abstract
Background and Aim: Deep venous thrombosis (DVT) of the lower extremities is common in Covid-19 patients. Interleukin (IL)-6 and P-selectin were found to be elevated in Covid-19 patients. The current study aimed to evaluate P-selectin and IL6 in Covid-19 patients with DVT and to explore its relation to clinical and laboratory parameters in those patients. Patients and methods: The present retrospective study included 150 hospitalized COVID-19 patients diagnosed on the basis of a positive result of reverse-transcriptase polymerase chain reaction (RT-PCR) test. Laboratory assessments were included for IL-6 and P selectin assessments via enzyme-linked immunosorbent assay. The primary outcome of the present study was the development of DVT detected by Doppler ultrasound (DU) evaluation of the lower extremities during the admission. Results: The present study included 150 hospitalized Covid-19 patients. DVT was developed in 59 patients (39.3%). DVP patients had significantly higher levels of P selectin [76.0 (63.0– 87.0) versus 63.0 (54.3– 75.0), p < 0.001] and IL-6 [37.0 (27.0– 49.0) versus 18.5 (13.5– 31.5), p < 0.001]. ROC curve analysis revealed good performance of P selectin [AUC (95% CI): 0.72 (0.64– 0.81)] and IL-6 [AUC (95% CI): 0.79 (0.71– 0.86)] in identification of DVT. Logistic regression analysis identified the presence of severe disease [OR (95% CI): 9.016 (3.61– 22.49), p < 0.001], elevated P selectin [OR (95% CI): 1.032 (1.005– 1.059), p = 0.018] and elevated IL-6 [OR (95% CI): 1.062 (1.033– 1.091), p < 0.001] as significant predictors of DVT development in multivariate analysis. Conclusion: The present study identified a probable role of elevated P-selectin and IL-6 levels in the DVT development in hospitalized Covid-19 patients.
- Subjects
VENOUS thrombosis; COVID-19; INTERLEUKIN-6; HOSPITAL patients; ENZYME-linked immunosorbent assay
- Publication
International Journal of General Medicine, 2022, Vol 15, p5599
- ISSN
1178-7074
- Publication type
Article
- DOI
10.2147/IJGM.S357097