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- Title
Correlations of PCSK9 and LDLR Gene Polymorphisms and Serum PCSK9 Levels With Atherosclerosis and Lipid Metabolism in Patients on Maintenance Hemodialysis.
- Authors
Cui, Jun; Qiu, Yuxiang; Kang, Ningsu; Lu, Jianxun; Zheng, Lu
- Abstract
This study is aimed at investigating the correlations of PCSK9 and LDLR gene polymorphisms as well as serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels with atherosclerosis and lipid metabolism in patients on maintenance hemodialysis (HD). A single nucleotide polymorphism at the E670G locus of the PCSK9 gene and the rs688 locus of the LDLR gene was analyzed by polymerase chain reaction–restriction fragment length polymorphism. All study subjects' blood lipid (triglyceride [TG], total cholesterol [TC], high‐density lipoprotein cholesterol [HDL‐C], and low‐density lipoprotein cholesterol [LDL‐C]) concentrations and lipoprotein(a) and PCSK9 levels were measured. The differences in blood lipid levels between different genotypes of the E670G locus of the PCSK9 gene and the rs688 locus of the LDLR gene in patients on maintenance HD with atherosclerosis were compared. Patients on maintenance HD with atherosclerosis at the E670G locus of the PCSK9 gene AG + GG genotype had higher levels of TG, TC, LDL‐C, and lipoprotein(a) than the AA genotype, and lower levels of HDL‐C than the AA genotype. Patients on maintenance HD with atherosclerosis at the rs688 locus of the LDLR gene CT + TT genotype had higher levels of TG, TC, LDL‐C, and lipoprotein(a) than the CC genotype, and lower levels of HDL‐C than the CC genotype. Serum PCSK9 contents in patients on maintenance HD with atherosclerosis were positively correlated with lipid indices (TG, TC, LDL‐C, and lipoprotein(a)) and carotid ultrasound indices (intima‐media thickness and resistance index), and negatively correlated with HDL‐C, maximum systolic blood flow velocity, and minimum diastolic blood flow velocity (all P <.05).
- Subjects
LIPID metabolism; TRIGLYCERIDES; RESEARCH; CAROTID intima-media thickness; GENETIC polymorphisms; PROTEOLYTIC enzymes; CELL receptors; LOW density lipoproteins; ATHEROSCLEROSIS; COMPARATIVE studies; RESEARCH funding; GENOTYPES; GENOMICS; DESCRIPTIVE statistics; HEMODIALYSIS; POLYMERASE chain reaction; HIGH density lipoproteins; STATISTICAL correlation; BLOOD
- Publication
Journal of Clinical Pharmacology, 2023, Vol 63, Issue 12, p1430
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1002/jcph.2332