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- Title
Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation.
- Authors
van Beynum, Ingrid M.; Kapusta, Livia; den Heijer, Martin; Vermeulen, Sita H.H.M.; Kouwenberg, Margreet; Daniëls, Otto; Blom, Henk J.
- Abstract
Aims Periconceptional folate supplementation prevents neural tube defects and possibly congenital heart defects (CHD) as well. The search for candidate genes involved in the folate metabolism includes the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism. We studied the association between MTHFR 677C>T variants and CHD risk. The interaction with periconceptional folate supplementation was also investigated.
- Publication
European Heart Journal, 2006, Vol 27, Issue 8, p981
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehi815