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- Title
Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis.
- Authors
Wu, Huihong; Wang, Siting; Chen, Weiyou; Zhan, Xinli; Xiao, Zengming; Jiang, Hua; Wei, Qingjun
- Abstract
Background: An increasing number of studies have investigated associations between collagen IX alpha 2 chain (COL9A2) and collagen IX alpha 3 chain (COL9A3) gene polymorphisms and the risk of lumbar disc degeneration (LDD). However, these studies have yielded contradictory results. The purpose of this meta-analysis is to investigate the association between the collagen IX gene polymorphisms (rs12077871, rs12722877, rs7533552 in COL9A2; rs61734651 in COL9A3) and LDD. Methods: All relevant articles were collected from PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI). The last electronic search was performed on September 1, 2017. The allele/genotype frequencies were extracted from each study. The odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of associations under the five comparison genetic models. Statistical analysis was performed by Review Manager (RevMan) 5.31 software. Results: The meta-analysis of 10 case-control studies, including 2102 LDD cases and 2507 controls, indicated that COL9A2 gene (rs12077871, rs12722877, rs7533552) and COL9A3 gene (rs61734651) polymorphisms were not associated with LDD (rs12077871: T vs. C, OR = 1.85, 95% CI = 0.87–3.91, <italic>P</italic> = 0.11; rs12722877: G vs. C, OR = 0.83, 95% CI = 0.69–1.01, <italic>P</italic> = 0.06; rs7533552: G vs. A, OR = 1.11, 95% CI = 0.98–1.25, <italic>P</italic> = 0.09; rs61734651: T vs. C, OR = 1.57, 95% CI = 0.51–4.84, <italic>P</italic> = 0.43). The Egger text and the Begg funnel plot did not show any evidence of publication bias. Conclusion: rs12077871, rs12722877, and rs7533552 variants in COL9A2 and rs61734651 variant in COL9A3 were not significantly associated with a predisposition to LDD. Large-scale and well-designed studies are needed to confirm this conclusion.
- Subjects
ALLELES; COLLAGEN; CONFIDENCE intervals; GENETIC polymorphisms; INTERVERTEBRAL disk; LUMBAR vertebrae; SPINE diseases; MEDLINE; META-analysis; ONLINE information services; SYSTEMATIC reviews; DATA analysis software; ODDS ratio; GENOTYPES
- Publication
Journal of Orthopaedic Surgery & Research, 2018, Vol 13, p1
- ISSN
1749-799X
- Publication type
Article
- DOI
10.1186/s13018-018-0750-0