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- Title
Immunological unresponsiveness in mice II. CELLULAR BASIS OF IMMUNOLOGICAL UNRESPONSIVENESS INDUCED IN FOETAL AND NEONATAL MICE BY TRANSFER OF HUMAN γ-GLOBULIN BY THE MATERNAL ROUTE.
- Authors
Shinka, S.; Komatsu, T.; Dohi, Y.; Amano, T.
- Abstract
The cellular basis of the mechanism of immunological tolerance to human γ-globulin (HγG) induced in foetal and neonatal mice by materno-foetal or materno-neonatal transfer after a single injection of tolerogen (deaggregated HγG) into the mothers was investigated using a cell transfer system and assays of passive haemagglutinating antibodies and plaque-forming cells to HγG. The results demonstrated that B cells are mainly involved in the tolerance induced on the fourteenth day of gestation, whereas inactivation of T cells may account for the tolerance induced on the eighteenth day of gestation and in the neonatal stage. Treatment of the mothers with tolerogen and then anti-HγG serum reduced the tolerance induced on the fourteenth day of gestation, but did not affect that induced on the eighteenth day of gestation and in the neonatal stage. Cell transfer experiments showed that B-cell tolerance induced on the fourteenth day of gestation was prevented by passive antibody, while T-cell tolerance induced on the eighteenth day of gestation and in the neonatal stage was not affected by passive antibody. Assay of the anti-DNP antibody response after immunization with DNP10-HγG showed that treatment of mice with the tolerogen on the eighteenth day of gestation, but not the fourteenth day of gestation, inactivated HγG-reactive helper cells. The significance of these results is discussed in relation to the results of the cell transfer experiments described as above.
- Subjects
IMMUNE response; GLOBULINS; FETUS; LABORATORY mice; B cells; MEDICAL research
- Publication
Immunology, 1979, Vol 37, Issue 1, p83
- ISSN
0019-2805
- Publication type
Article