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- Title
Shareability of antibacterial and osteoblastic‐proliferation activities of zinc‐doped hydroxyapatite nanoparticles in vitro.
- Authors
Okada, Masanori; Oshita, Mari; Kataoka, Minami; Azuma, Yoshinao; Furuzono, Tsutomu
- Abstract
Four types of zinc (Zn)‐doped hydroxyapatite (Zn‐HAp) nanoparticles were prepared using calcium nitrate tetrahydrate as an anti‐sintering agent during calcination at 600°C for 1 hr, to prevent calcination‐induced aggregation. The Zn content of the nanopowders was determined at 0, 4.3, 9.2, and 14.7% [Zn/(Ca + Zn) × 100] using inductively coupled plasma atomic emission spectroscopic analysis. Based on X‐ray diffraction analysis, the products were shown to possess an apatite structure without other crystalline impurities. The cell parameters of Zn‐HAp nanoparticles decreased with increasing of Zn content in the HAp structures. This tendency implies that Zn ions substituted for Ca sites in the HAp crystal lattices. To investigate the biological effects of Zn‐HAp nanoparticles, cell proliferation activity of MC3T3‐E1 osteoblasts and antibacterial activity against Escherichia coli were evaluated in vitro. According to the results obtained, Zn‐HAp nanoparticles containing of 14.7% Zn ions was noticeable shown shareability of the conflicting activities at 0.1 mg/mL.
- Subjects
HYDROXYAPATITE; ANTIBACTERIAL agents; NANOPARTICLES; CRYSTAL lattices; CALCIUM nitrate
- Publication
Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2022, Vol 110, Issue 4, p799
- ISSN
1552-4973
- Publication type
Article
- DOI
10.1002/jbm.b.34959