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- Title
CEST and PARACEST MR contrast agents.
- Authors
Hancu I; Dixon WT; Woods M; Vinogradov E; Sherry AD; Lenkinski RE; Hancu, Ileana; Dixon, W Thomas; Woods, Mark; Vinogradov, Elena; Sherry, A Dean; Lenkinski, Robert E
- Abstract
In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.
- Subjects
TISSUES; MAGNETIZATION; PROTONS; MULTIPLE sclerosis; MAGNETIC resonance imaging; CONTRAST media
- Publication
Acta Radiologica, 2010, Vol 51, Issue 8, p910
- ISSN
0284-1851
- Publication type
journal article
- DOI
10.3109/02841851.2010.502126