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- Title
Is hypertension an autoimmune disease?
- Authors
Pober, Jordan S.
- Abstract
T cells are required for significant blood pressure elevation in mouse models of hypertension. Recent evidence suggests that the treatments that raise blood pressure in these animal models also cause oxidation within DCs, resulting in formation of isoketal adducts of self-proteins, which activate antigen-presenting functions of these cells and serve as a source of modified self-antigens. T cells specific for these modified self-antigens then produce cytokines that promote blood pressure elevation, consistent with the idea that hypertension is an autoimmune response to altered self. Here, I will review the new evidence for this idea put forth by Kirabo and colleagues in this issue of the JCI, identify a number of as yet unanswered questions, and discuss some of the therapeutic implications.
- Subjects
HYPERTENSION; T cells; BLOOD pressure measurement; AUTOANTIGENS; LABORATORY mice
- Publication
Journal of Clinical Investigation, 2014, Vol 124, Issue 10, p4234
- ISSN
0021-9738
- Publication type
Article
- DOI
10.1172/JCI77766