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Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-02256-5
By:
- Choudhary, Ishita;
- Vo, Thao;
- Paudel, Kshitiz;
- Wen, Xue;
- Gupta, Richa;
- Kesimer, Mehmet;
- Patial, Sonika;
- Saini, Yogesh
Publication type:
Article
Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 7, p. 3047, doi. 10.1172/JCI73469
By:
- Henderson, Ashley G.;
- Ehre, Camille;
- Button, Brian;
- Abdullah, Lubna H.;
- Li-Heng Cai;
- Leigh, Margaret W.;
- DeMaria, Genevieve C.;
- Matsui, Hiro;
- Donaldson, Scott H.;
- Davis, C. William;
- Sheehan, John K.;
- Boucher, Richard C.;
- Kesimer, Mehmet
Publication type:
Article
Impact of COVID-19 pandemic on hand injuries.
Published in:
Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi, 2022, v. 28, n. 7, p. 911, doi. 10.14744/tjtes.2021.75100
By:
- Özkan, Melekber Çavuş;
- Saraç, Ömer;
- Kesimer, Mehmet Deniz;
- Doğan, Zeynep Akdeniz;
- Durmus Kocaaslan, Fatma Nihal;
- Sacak, Bulent
Publication type:
Article
Little Cigars are More Toxic than Cigarettes and Uniquely Change the Airway Gene and Protein Expression.
Published in:
Scientific Reports, 2017, p. 46239, doi. 10.1038/srep46239
By:
- Ghosh, Arunava;
- Abdelwahab, Sabri H.;
- Reeber, Steven L.;
- Reidel, Boris;
- Marklew, Abigail J.;
- Garrison, Andrew J.;
- Lee, Shernita;
- Dang, Hong;
- Herring, Amy H.;
- Glish, Gary L.;
- Kesimer, Mehmet;
- Tarran, Robert
Publication type:
Article
Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs.
Published in:
PLoS ONE, 2015, v. 10, n. 9, p. 1, doi. 10.1371/journal.pone.0138988
By:
- Kesimer, Mehmet;
- Cullen, John;
- Cao, Rui;
- Radicioni, Giorgia;
- Mathews, Kyle G.;
- Seiler, Gabriela;
- Gookin, Jody L.
Publication type:
Article
Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non–Cystic Fibrosis Bronchiectasis.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2024, v. 209, n. 4, p. 374, doi. 10.1164/rccm.202306-1093OC
By:
- Asakura, Takanori;
- Okuda, Kenichi;
- Chen, Gang;
- Dang, Hong;
- Kato, Takafumi;
- Mikami, Yu;
- Schworer, Stephen A.;
- Gilmore, Rodney C.;
- Radicioni, Giorgia;
- Hawkins, Padraig;
- Barbosa Cardenas, Selene Margarita;
- Saito, Minako;
- Cawley, Anne Marie;
- De la Cruz, Gabriela;
- Chua, Michael;
- Alexis, Neil E.;
- Masugi, Yohei;
- Noone, Peadar G.;
- Ribeiro, Carla M. P.;
- Kesimer, Mehmet
Publication type:
Article
Mucins MUC5AC and MUC5B in the Airways: MUCing around Together.
Published in:
2022
By:
- Kesimer, Mehmet
Publication type:
Editorial
Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of .
Published in:
2022
By:
- Costain, Gregory;
- Zhen Liu;
- Mennella, Vito;
- Radicioni, Giorgia;
- Goczi, Adrienn N.;
- Albulescu, Alexandra;
- Walker, Susan;
- Ngan, Bo;
- Manson, David;
- Vali, Reza;
- Khan, Meraj;
- Palaniyar, Nades;
- Hill, David B.;
- Hall, David A.;
- Marshall, Christian R.;
- Knowles, Michael;
- Zariwala, Maimoona A.;
- Kesimer, Mehmet;
- Dell, Sharon D.;
- Liu, Zhen
Publication type:
journal article
Another Warning Sign: High Nicotine Content in Electronic Cigarettes Disrupts Mucociliary Clearance, the Essential Defense Mechanism of the Lung.
Published in:
2019
By:
- Kesimer, Mehmet
Publication type:
Editorial
Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.
Published in:
2019
By:
- Okuda, Kenichi;
- Chen, Gang;
- Subramani, Durai B;
- Wolf, Monroe;
- Gilmore, Rodney C;
- Kato, Takafumi;
- Radicioni, Giorgia;
- Kesimer, Mehmet;
- Chua, Michael;
- Dang, Hong;
- Livraghi-Butrico, Alessandra;
- Ehre, Camille;
- Doerschuk, Claire M;
- Randell, Scott H;
- Matsui, Hirotoshi;
- Nagase, Takahide;
- O'Neal, Wanda K;
- Boucher, Richard C
Publication type:
journal article
Mucin Concentrations and Peripheral Airway Obstruction in Chronic Obstructive Pulmonary Disease.
Published in:
2018
By:
- Kesimer, Mehmet;
- Smith, Benjamin M;
- Ceppe, Agathe;
- Ford, Amina A;
- Anderson, Wayne H;
- Barr, R Graham;
- O'Neal, Wanda K;
- Boucher, Richard C;
- SPIROMICS Investigative Group
Publication type:
Letter
At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.
Published in:
2018
By:
- Martinez, Fernando J.;
- Han, MeiLan K.;
- Allinson, James P.;
- Barr, R. Graham;
- Boucher, Richard C.;
- Calverley, Peter M. A.;
- Celli, Bartolome R.;
- Christenson, Stephanie A.;
- Crystal, Ronald G.;
- Fagerås, Malin;
- Freeman, Christine M.;
- Groenke, Lars;
- Hoffman, Eric A.;
- Kesimer, Mehmet;
- Kostikas, Kostantinos;
- Paine III, Robert;
- Rafii, Shahin;
- Rennard, Stephen I.;
- Segal, Leopoldo N.;
- Shaykhiev, Renat
Publication type:
journal article
E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion.
Published in:
2018
By:
- Reidel, Boris;
- Radicioni, Giorgia;
- Clapp, Phillip W.;
- Ford, Amina A.;
- Abdelwahab, Sabri;
- Rebuli, Meghan E.;
- Haridass, Prashamsha;
- Alexis, Neil E.;
- Jaspers, Ilona;
- Kesimer, Mehmet
Publication type:
journal article
Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia.
Published in:
2018
By:
- Abdullah, Lubna H.;
- Coakley, Raymond;
- Webster, Megan J.;
- Yunxiang Zhu;
- Tarran, Robert;
- Radicioni, Giorgia;
- Kesimer, Mehmet;
- Boucher, Richard C.;
- Davis, C. William;
- Ribeiro, Carla M. P.;
- Zhu, Yunxiang
Publication type:
journal article
The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.
Published in:
2015
By:
- Anderson, Wayne H;
- Coakley, Raymond D;
- Button, Brian;
- Henderson, Ashley G;
- Zeman, Kirby L;
- Alexis, Neil E;
- Peden, David B;
- Lazarowski, Eduardo R;
- Davis, C William;
- Bailey, Summer;
- Fuller, Fred;
- Almond, Martha;
- Qaqish, Bahjat;
- Bordonali, Elena;
- Rubinstein, Michael;
- Bennett, William D;
- Kesimer, Mehmet;
- Boucher, Richard C
Publication type:
journal article
The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2015, v. 192, n. 2, p. 182, doi. 10.1164/rccm.201412-2230oc
By:
- Anderson, Wayne H.;
- Coakley, Raymond D.;
- Button, Brian;
- Henderson, Ashley G.;
- Zeman, Kirby L.;
- Alexis, Neil E.;
- Peden, David B.;
- Lazarowski, Eduardo R.;
- Davis, C. William;
- Bailey, Summer;
- Fuller, Fred;
- Almond, Martha;
- Qaqish, Bahjat;
- Bordonali, Elena;
- Rubinstein, Michael;
- Bennett, William D.;
- Kesimer, Mehmet;
- Boucher, Richard C.
Publication type:
Article
Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2022, v. 67, n. 2, p. 253, doi. 10.1165/rcmb.2021-0359OC
By:
- Batson, Bethany D.;
- Zorn, Bryan T.;
- Radicioni, Giorgia;
- Livengood, Stephanie S.;
- Kumagai, Tadahiro;
- Hong Dang;
- Ceppe, Agathe;
- Clapp, Phillip W.;
- Tunney, Michael;
- Elborn, J. Stuart;
- McElvaney, Noel G.;
- Muhlebach, Marianne S.;
- Boucher, Richard C.;
- Tiemeyer, Michael;
- Wolfgang, Matthew C.;
- Kesimer, Mehmet
Publication type:
Article
Cigarillos Compromise the Mucosal Barrier and Protein Expression in Airway Epithelia.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2020, v. 63, n. 6, p. 767, doi. 10.1165/rcmb.2019-0085OC
By:
- Abdelwahab, Sabri H.;
- Reidel, Boris;
- Martin, Jessica R.;
- Ghosh, Arunava;
- Keating, James E.;
- Haridass, Prashamsha;
- Carpenter, Jerome;
- Glish, Gary L.;
- Tarran, Robert;
- Doerschuk, Claire M.;
- Kesimer, Mehmet
Publication type:
Article
Chronic Exposure to Beta-Blockers Attenuates Inflammation and Mucin Content in a Murine Asthma Model.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2008, v. 38, n. 3, p. 256, doi. 10.1165/rcmb.2007-0279RC
By:
- Nguyen, Long P.;
- Omoluabi, Ozozoma;
- Parra, Sergio;
- Frieske, Joanna M.;
- Clement, Cecilia;
- Ammar-Aouchiche, Zoulikha;
- Ho, Samuel B.;
- Ehre, Camille;
- Kesimer, Mehmet;
- Knoll, Brian J.;
- Tuvim, Michael J.;
- Dickey, Burton F.;
- Bond, Richard A.
Publication type:
Article
Cigarette smoke modifies and inactivates SPLUNC1, leading to airway dehydration.
Published in:
FASEB Journal, 2018, v. 32, n. 12, p. 6559, doi. 10.1096/fj.201800345R
By:
- Moore, Patrick J.;
- Reidel, Boris;
- Ghosh, Arunava;
- Sesma, Juliana;
- Kesimer, Mehmet;
- Tarran, Robert
Publication type:
Article
Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways.
Published in:
FASEB Journal, 2012, v. 26, n. 10, p. 4348, doi. 10.1096/fj.12-207431
By:
- Hobbs, Carey A.;
- Blanchard, Maxime G.;
- Kellenberger, Stephan;
- Bencharit, Sompop;
- Rui Cao;
- Kesimer, Mehmet;
- Walton, William G.;
- Redinbo, Matthew R.;
- Stutts, M. Jackson;
- Tarran, Robert
Publication type:
Article
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Published in:
FASEB Journal, 2009, v. 23, n. 6, p. 1858, doi. 10.1096/fj.08-119131
By:
- Kesimer, Mehmet;
- Scull, Margaret;
- Brighton, Brian;
- DeMaria, Genevieve;
- Burns, Kimberlie;
- O'Neal, Wanda;
- Pickles, Raymond J.;
- Sheehan, John K.
Publication type:
Article
IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis.
Published in:
2019
By:
- Gang Chen;
- Ling Sun;
- Takafumi Kato;
- Kenichi Okuda;
- Martino, Mary B.;
- Abzhanova, Aiman;
- Lin, Jennifer M.;
- Gilmore, Rodney C.;
- Batson, Bethany D.;
- O'Neal, Yvonne K.;
- Volmer, Allison S.;
- Hong Dang;
- Yangmei Deng;
- Randell, Scott H.;
- Button, Brian;
- Livraghi-Butrico, Alessandra;
- Kesimer, Mehmet;
- Ribeiro, Carla M. P.;
- O'Neal, Wanda K.;
- Boucher, Richard C.
Publication type:
journal article
Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.
Published in:
Science Translational Medicine, 2019, v. 11, n. 486, p. N.PAG, doi. 10.1126/scitranslmed.aav3488
By:
- Esther, Charles R.;
- Muhlebach, Marianne S.;
- Ehre, Camille;
- Wolfgang, Matthew C.;
- Kesimer, Mehmet;
- Markovetz, Matthew R.;
- Garbarine, Ian C.;
- Zorn, Bryan;
- Morrison, Cameron B.;
- Delion, Martial F.;
- Boucher, Richard C.;
- Hill, David B.;
- Ramsey, Kathryn A.;
- Turkovic, Lidija;
- Stick, Stephen M.;
- Forest, M. Gregory;
- Seim, Ian;
- Thelin, William R.;
- Villalon, Diane;
- Sabater, Juan R.
Publication type:
Article
Allergic asthma is distinguished by sensitivity of allergen-specific CD4<sup>+</sup> T cells and airway structural cells to type 2 inflammation.
Published in:
Science Translational Medicine, 2016, v. 8, n. 359, p. 1, doi. 10.1126/scitranslmed.aag1370
By:
- Cho, Josalyn L.;
- Ling, Morris F.;
- Adams, David C.;
- Faustino, Lucas;
- Islam, Sabina A.;
- Afshar, Roshi;
- Griffith, Jason W.;
- Harris, Robert S.;
- Aylwin Ng;
- Radicioni, Giorgia;
- Ford, Amina A.;
- Han, Andre K.;
- Xavier, Ramnik;
- Kwok, William W.;
- Boucher, Richard;
- Moon, James J.;
- Hamilos, Daniel L.;
- Kesimer, Mehmet;
- Suter, Melissa J.;
- Medoff, Benjamin D.
Publication type:
Article
Proteomic and biochemical analysis of exosomes isolated from human tracheobronchial epithelial cell culture secretions.
Published in:
FASEB Journal, 2007, v. 21, n. 5, p. A268, doi. 10.1096/fasebj.21.5.a268-a
By:
- Kesimer, Mehmet;
- Matthews, Garrett;
- DeMaria, Genevieve;
- Henderson, Ashley G.;
- Pickles, Raymond J.;
- Sheehan, John K.
Publication type:
Article
Effect of the pandemic on surgical procedures in a tertiary care hospital: A retrospective review.
Published in:
Turkish Journal of Surgery / Bilimsel Tip Yayinevi, 2022, v. 38, n. 3, p. 243, doi. 10.47717/turkjsurg.2022.5256
By:
- Özkan, Melekber Çavuş;
- Saçak, Bülent;
- Kesimer, Mehmet Deniz;
- Şahin, Bahadır;
- Uğurlu, Mustafa Ümit;
- Sirzai, Esra Yamansavcı;
- Sakar, Mustafa;
- İD,İlker Çiçek, Aslan Aykut7;
- Yumuşakhuylu, Ali Cemal
Publication type:
Article
Vaping additives cannabinoid oil and vitamin E acetate adhere to and damage the human airway epithelium.
Published in:
Journal of Applied Toxicology, 2023, v. 43, n. 5, p. 680, doi. 10.1002/jat.4415
By:
- Reidel, Boris;
- Abdelwahab, Sabri;
- Wrennall, Joe Alexander;
- Clapp, Phillip W.;
- Beers, Jessica L.;
- Jackson, Klarissa D.;
- Tarran, Robert;
- Kesimer, Mehmet
Publication type:
Article
Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-77229-1
By:
- Kim, Victor;
- Jeong, Stephanie;
- Zhao, Huaqing;
- Kesimer, Mehmet;
- Boucher, Richard C.;
- Wells, J. Michael;
- Christenson, Stephanie A.;
- Han, MeiLan K.;
- Dransfield, Mark;
- Paine III, Robert;
- Cooper, Christopher B.;
- Barjaktarevic, Igor;
- Bowler, Russell;
- Curtis, Jeffrey L.;
- Kaner, Robert J.;
- O'Beirne, Sarah L.;
- O'Neal, Wanda K.;
- Rennard, Stephen I.;
- Martinez, Fernando J.;
- Woodruff, Prescott G.
Publication type:
Article
Is bipolar hemiarthroplasty an appropriate type of hip articulation following proximal femoral or total femoral resections for musculoskeletal malignancies?
Published in:
Archives of Orthopaedic & Trauma Surgery, 2022, v. 142, n. 2, p. 331, doi. 10.1007/s00402-021-03980-3
By:
- Saglam, Fevzi;
- Baysal, Ozgur;
- Sirin, Evrim;
- Sofulu, Omer;
- Kesimer, Mehmet Deniz;
- Erol, Bulent
Publication type:
Article
Membrane-bound mucins of the airway mucosal surfaces are densely decorated with keratan sulfate: revisiting their role in the Lung's innate defense.
Published in:
Glycobiology, 2021, v. 31, n. 4, p. 436, doi. 10.1093/glycob/cwaa089
By:
- Carpenter, Jerome;
- Kesimer, Mehmet
Publication type:
Article
Analyzing the functions of large glycoconjugates through the dissipative properties of their absorbed layers using the gel-forming mucin MUC5B as an example.
Published in:
Glycobiology, 2008, v. 18, n. 6, p. 463, doi. 10.1093/glycob/cwn024
By:
- Mehmet Kesimer;
- John K Sheehan
Publication type:
Article
Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization.
Published in:
2016
By:
- Dickey, Burton F;
- Fahy, John V;
- Kesimer, Mehmet;
- Boucher, Richard C;
- Evans, Christopher M;
- Thornton, David
Publication type:
Letter

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