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- Title
Fibroblast Growth Factor 23 and Its Receptors.
- Authors
Xijie Yu; White, Kenneth E
- Abstract
Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Autosomal dominant hypophosphatemic rickets is characterized by hypophosphatemia with inappropriately normal 1,25-dihydroxyvitamin D concentrations, as well as bone pain, fracture and rickets. This phenotype parallels that of patients with tumor induced osteomalacia (TIO), X-linked hypophosphatemic rickets (XLH), and fibrous dysplasia (FD), in whom elevated serum FGF23 levels are often observed. The fibroblast growth factor receptors (FGFR1–4) play key roles in skeletal development, as well as in normal metabolic processes. Several FGFR isoforms that potentially mediate the activity of FGF23 have been implicated. In the short term, these findings will lead to further understanding of FGF23 function, and potentially in the long term, to targeted therapies in disorders of hypo- and hyperphosphatemia that involve FGF23.
- Subjects
FIBROBLAST growth factors; FAMILIAL hypophosphatemia; RICKETS; PHOSPHATES; VITAMIN D; OSTEOMALACIA; FIBROUS dysplasia of bone
- Publication
Therapeutic Apheresis & Dialysis, 2005, Vol 9, Issue 4, p308
- ISSN
1744-9979
- Publication type
Article
- DOI
10.1111/j.1744-9987.2005.00287.x