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- Title
Gaps in Serologic Immunity against Contemporary Swine-Origin Influenza A Viruses among Healthy Individuals in the United States.
- Authors
Lorbach, Joshua N.; Fitzgerald, Theresa; Nolan, Carolyn; Nolting, Jacqueline M.; Treanor, John J.; Topham, David J.; Bowman, Andrew S.; Perez, Daniel R
- Abstract
Influenza A Viruses (IAV) in domestic swine (IAV-S) are associated with sporadic zoonotic transmission at the human–animal interface. Previous pandemic IAVs originated from animals, which emphasizes the importance of characterizing human immunity against the increasingly diverse IAV-S. We analyzed serum samples from healthy human donors (n = 153) using hemagglutination-inhibition (HAI) assay to assess existing serologic protection against a panel of contemporary IAV-S isolated from swine in the United States (n = 11). Age-specific seroprotection rates (SPR), which are the proportion of individuals with HAI ≥ 1:40, corresponded with lower or moderate pandemic risk classifications for the multiple IAV-S examined (one H1-δ1, one H1-δ2, three H3-IVA, one H3-IVB, one H3-IVF). Individuals born between 2004 and 2013 had SPRs of 0% for the five classified H3 subtype IAV-S, indicating youth may be particularly predisposed to infection with these viruses. Expansion of existing immunologic gaps over time could increase likelihood of future IAV-S spillover to humans and facilitate subsequent sustained human-to-human transmission resulting in disease outbreaks with pandemic potential.
- Subjects
UNITED States; INFLUENZA A virus; EPIDEMICS; INFECTIOUS disease transmission; VIRUS diseases; PANDEMICS; HUMAN in vitro fertilization
- Publication
Viruses (1999-4915), 2021, Vol 13, Issue 1, p127
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v13010127