We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Silk‐Inspired In Situ Hydrogel with Anti‐Tumor Immunity Enhanced Photodynamic Therapy for Melanoma and Infected Wound Healing.
- Authors
Tang, Xiaoxuan; Chen, Xiaoli; Zhang, Siming; Gu, Xinyi; Wu, Ronghua; Huang, Tingting; Zhou, Zhihao; Sun, Cheng; Ling, Jue; Liu, Mei; Yang, Yumin
- Abstract
Easy cancer recurrence and wound infections have been clinical challenges after surgical treatment of melanoma. Herein, a silk‐inspired in situ gelation system containing methacrylated silk fibroin (SF) and chlorine e6 for improved cancer therapy with enhanced wound healing is developed. Favored by the macrophage recruitment capacity of the SF hydrogel, promising antitumor immune responses can be turned "on" via near infrared irradiation in a controllable manner to achieve combination therapy with photodynamic therapy to significantly suppress melanoma recurrence. Moreover, the effective photodynamic antibacterial activity of this bioactive system with the capacity of light‐controllable modulating macrophage phenotype promotes remarkable tissue ingrowth with hair follicle regeneration for Staphylococcus aureus infected wound healing. Thus, this multifunctional silk‐based hydrogel system, as a desirable wound dressing, provides a new platform for promising melanoma therapy and skin regeneration.
- Subjects
PHOTODYNAMIC therapy; CANCER relapse; SILK fibroin; MELANOMA; IMMUNITY; WOUND healing
- Publication
Advanced Functional Materials, 2021, Vol 31, Issue 17, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202101320