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- Title
Screening of Lichen Extracts Using Tyrosinase Inhibition and Toxicity Against Artemia salina.
- Authors
Honda, Neli Kika; Gonçalve, Kerolayne; Gardini Brandão, Luiz Fabrício; Coelho, Roberta Gomes; Michelettia, Ana Camila; Spielmann, Adriano Afonso; Canêz, Luciana Silva
- Abstract
Nine lichen extracts were evaluated for tyrosinase inhibition and toxicity against Arteμia salina larvae. Extract coμpositions were investigated by TLC and NMR analysis. The activity of constituents against tyrosinase was evaluated by bioautography, and the percent of inhibition was calculated based on the dopachroμe produced during a set tiμe interval. Cladia aggregata, Cladonia diμorphoclada, Stereocaulon raμulosuμ and Stereocaulon μicrocarpuμ extracts were active for tyrosinase inhibition. Barbatic, usnic, anziaic acids and an unidentified coμpound present in the extracts, are possibly responsible for tyrosinase inhibition. Cladia aggregata, Cladonia crispatula, Cladonia furcata, Lobaria erosa, Punctelia canaliculata and S. μicrocarpuμ proved to be less toxic to A. salina (LC50 > 500 μg/μL) than Cladonia confusa and S. raμulosuμ (LC50 45.0 and 100.3 μg/μL, respectively), while the extract of C. diμorphoclada was highly toxic (LC50 < 10 μg/μL).
- Subjects
LICHENS; PHENOL oxidase; PHENOLS
- Publication
Orbital: The Electronic Journal of Chemistry, 2016, Vol 8, Issue 3, p181
- ISSN
1984-6428
- Publication type
Article
- DOI
10.17807/orbital.v8i3.842