We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Unraveling polyketide synthesis in members of the genus Aspergillus.
- Authors
Yi-Ming Chiang; Oakley, Berl; Keller, Nancy; Wang, Clay
- Abstract
Aspergillus species have the ability to produce a wide range of secondary metabolites including polyketides that are generated by multi-domain polyketide synthases (PKSs). Recent biochemical studies using dissected single or multiple domains from PKSs have provided deep insight into how these PKSs control the structural outcome. Moreover, the recent genome sequencing of several species has greatly facilitated the understanding of the biosynthetic pathways for these secondary metabolites. In this review, we will highlight the current knowledge regarding polyketide biosynthesis in Aspergillus based on the domain architecture of non-reducing, highly reducing, and partially reducing PKSs, and PKS-non-ribosomal peptide synthetases.
- Subjects
METABOLITES; POLYKETIDES; BIOMARKERS; ASPERGILLUS; BIOCHEMICAL engineering; PEPTIDE synthesis; FUNGI classification; BIOLOGICAL products; CHEMICAL ecology
- Publication
Applied Microbiology & Biotechnology, 2010, Vol 86, Issue 6, p1719
- ISSN
0175-7598
- Publication type
Article
- DOI
10.1007/s00253-010-2525-3