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- Title
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
- Authors
Liu, Zhihong; Sun, Chaohong; Olejniczak, Edward T.; Meadows, Robert P.; Betz, Stephen F.; Oost, Thorsten; Herrmann, Julia; Wu, Joe C.; Fesik, Stephen W.
- Abstract
Describes the structural basis for molecular recognition between the protein Smac/DIABLO and the inhibitor-of-apoptosis proteins (IAP). Determination of the solution structure of the BIR3 domain of X-linked IAP complexed with a functionally active nine-residue peptide derived from the N terminus of SMAC; Implications for the treatment of cancers that overexpress IAPs.
- Subjects
APOPTOSIS; CELL death; MOLECULAR recognition; CHEMICAL inhibitors; CANCER treatment
- Publication
Nature, 2000, Vol 408, Issue 6815, p1004
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/35050006