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- Title
Sorbitan Monolaurate 20 as a Potential Skin Permeation Enhancer in Transdermal Patches.
- Authors
Mukherjee, Biswajit; Kanupriya; Mahapatra, Sushmita; Das, Surajit; Patra, Balaram
- Abstract
The objective of our present work was to prepare transdermal matrix patches containing the drug, diclofenac diethylamine with various polymeric combinations of polyvinylpyrrolidone and ethylcellulose and to study the mechanism of release of the drug from the patches and its skin permeation. Sorbitan monolaurate 20 (Span 20), a non-ionic surfactant was added to the concentrations (0.1% wt/vol), as a skin permeation enhancer to the drug, diclofenac diethylamine. In vitro skin permeation studies, with rat skin, using a modified Keshary-Chien diffusion cell, were carried out to establish the most favorable polymeric combination and the impact of Span 20 was also studied. Extensive electron microscopy studies were conducted and the underlying mechanism of drug release from the patches and its permeation through skin are discussed. Cumulative amounts of drug released, per cm² of patch after 48 hours, were found to be 2.6111 mg, 3.53 mg. 2.498 mg, 3.373 mg, 3.716 mg, and 4.983 mg, in the formulations PA-1 (PVP: EC 1:2). PA-2 (PVP: EC 1:2 with enhancer), PA-3 (PVP: EC 1:3). PA-4 (PVP: EC 1:3 with enhancer), PA-5 (PVP: EC 3:5), and PA-6 (PVP: EC 3:5 with enhancer), respectively. There was about a 29% to 30% enhancement of skin permeation of the drug using Span 20. It is concluded here that the formulation PA-3 is the slowest in terms of skin permeation of the prepared transdermal matrix patches for diclofenac diethylamine and that Span 20 may be the best choice amongst the skin permeation enhancers to permeate the drug steadily. Moreover, extensive electron microscopic studies were conducted to understand drug distribution in the patches, drug release from the patches, and the permeation of drug through skin.
- Subjects
TRANSDERMAL medication; POVIDONE; DICLOFENAC; ETHYLCELLULOSE; ELECTRON microscopy
- Publication
Journal of Applied Research, 2005, Vol 5, Issue 1, p96
- ISSN
1537-064X
- Publication type
Article