We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Adherence to laboratory testing in pediatric liver transplant recipients.
- Authors
Ryan, Jamie L.; Dandridge, Laura M.; Fischer, Ryan T.
- Abstract
Background: The objectives of this retrospective cohort study are to describe rates of adherence to laboratory testing 6 months to 3 years post–liver transplantation and to examine demographic and clinical factors related to lab non‐adherence and the association with medication adherence and clinical outcomes. Methods: Medical chart review was conducted for 54 youth (mean age = 5.0 years) transplanted between 2003 and 2014. Lab adherence (≥80%) was measured as the proportion of completed labs out of the number expected. Immunosuppressant drug‐level variability was used as a proxy for medication adherence. Clinical outcomes included LAR, viral infection, hospitalization, and non‐routine clinic visit ≥12 months after transplant. Results: Lab adherence decreased substantially over time. Single‐parent household (aOR 5.86; 95% CI: 1.38‐24.93) and no history of early rejection (aOR 3.96; 95% CI: 1.04‐15.24) were independently associated with non‐adherence. Lab non‐adherence was significantly associated with medication non‐adherence (P <.05), LAR (P =.02), and non‐routine clinic visits (P =.03). Conclusions: Systematic monitoring of lab adherence may help in identifying pediatric LT recipients at increased risk for excessive healthcare use and adverse outcomes possibly due to poor disease management.
- Subjects
LIVER transplantation; TESTING laboratories; DISEASE management; PATIENT compliance; TREATMENT effectiveness
- Publication
Pediatric Transplantation, 2021, Vol 25, Issue 3, p1
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/petr.13899