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- Title
Female para-urethral adenocarcinoma: Histological and immunohistochemical study.
- Authors
KATO, HARUAKI; KOBAYASHI, SHINYA; ISLAM, AMH MANJURUL; NISHIZAWA, OSAMU
- Abstract
Female urethral cancer with a diverticular form is assumed to originate from the para-urethral duct, which is embryologically homologous to the male prostate gland. The purpose of the present paper was to investigate the female para-urethral adenocarcinomas histologically and immunohistochemically.Surgical specimens obtained from six female patients with para-urethral adenocarcinomas were examined histologically, and an immunohistochemical study using antibodies against carcinoembryonic antigen (CEA), prostate specific antigen (PSA), and chromogranin A was performed.On histologic examination, the female para-urethral cancers were divided into five cases of mucin-producing-type adenocarcinoma and one case of clear cell-type adenocarcinoma. All five mucin-producing-type adenocarcinomas were positive with anti-CEA, and two of them showed neuroendicrine differentiation. One of them showed a focally positive area with anti-PSA. The clear cell-type adenocarcinoma had no positive reactions to these antibodies.On the basis of histologic structure, positive CEA staining, and the presence of focal neuroendocrine differentiation, mucin-producing-type adenocarcinomas may arise from the proximal part of the para-urethral duct.
- Subjects
URETHRAL cancer; ADENOCARCINOMA; ANTIGENS; TUMOR classification; CARCINOEMBRYONIC antigen; IMMUNOHISTOCHEMISTRY
- Publication
International Journal of Urology, 2005, Vol 12, Issue 1, p117
- ISSN
0919-8172
- Publication type
Article
- DOI
10.1111/j.1442-2042.2004.00991.x