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- Title
The regulation of the B-cell gene expression programme by Pax5.
- Authors
Holmes, Melissa L; Pridans, Clare; Nutt, Stephen L
- Abstract
The activity of the transcription factor paired box gene 5 (Pax5) is essential for many aspects of B lymphopoiesis including the initial commitment to the lineage, immunoglobulin rearrangement, pre-B cell receptor signalling and maintaining cell identity in mature B cells. Deregulated or reduced Pax5 activity has also been implicated in B-cell malignancies both in human disease and mouse models. Candidate gene approaches and biochemical analysis have revealed that Pax5 regulates B lymphopoiesis by concurrently activating B cell-specific gene expression as well as repressing the expression of genes, many of which are associated with non-B cell lineages. These studies have been recently complemented with more exhaustive microarray studies, which have identified and validated a large panel of Pax5 target genes. These target genes reveal a gene regulatory network, with Pax5 at its centre that controls the B-cell gene expression programme.Immunology and Cell Biology (2008) 86, 47–53; doi:10.1038/sj.icb.7100134; published online 13 November 2007
- Subjects
B cells; TRANSCRIPTION factors; IMMUNOGLOBULINS; GENE expression; CELL receptors
- Publication
Immunology & Cell Biology, 2008, Vol 86, Issue 1, p47
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1038/sj.icb.7100134