We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Chronic hepatitis C infection is associated with insulin resistance and lipid profiles.
- Authors
Dai, Chia‐Yen; Yeh, Ming‐Lun; Huang, Chung‐Feng; Hou, Chen‐Hsiu; Hsieh, Ming‐Yen; Huang, Jee‐Fu; Lin, I‐Ling; Lin, Zu‐Yau; Chen, Shinn‐Chern; Wang, Liang‐Yen; Chuang, Wan‐Long; Yu, Ming‐Lung; Tung, Hung‐Da
- Abstract
Background and Aim Chronic hepatitis C virus ( HCV) infection has been suggested to be associated with non-insulin-dependent diabetes mellitus and lipid profiles. This study aimed to investigate the possible relationships of insulin resistance ( IR) and lipid profiles with chronic hepatitis C ( CHC) patients in Taiwan. Methods We enrolled 160 hospital-based CHC patients with liver biopsy and the 480 controlled individuals without CHC and chronic hepatitis B from communities without known history of non-insulin-dependent diabetes mellitus. Fasting plasma glucose, total cholesterol, high-density lipoprotein cholesterol ( HDL- C), low-density lipoprotein cholesterol ( LDL- C), triglycerides ( TGs), alanine aminotransferase, and serum insulin levels, and homeostasis model assessment ( HOMA-IR) were tested. Results When comparing factors between CHC patients, and sex- and age-matched controls who had no HCV infection, patients with HCV infection had a significantly higher alanine aminotransferase level, fasting plasma glucose level, insulin level, and HOMA-IR ( P < 0.001, P = 0.023, P = 0.017, and P = 0.011, respectively), and significantly lower TG level ( P = 0.023), total cholesterol, and HDL- C and LDL- C levels (all P < 0.001) than 480 controls. In multivariate logistic regression analyses, a low total cholesterol, a low TGs, and a high HOMA-IR are independent factors significantly associated with chronic HCV infection. In the 160 CHC patients (41 patients with high HOMA-IR [> 2.5]), a high body mass index, TGs, and HCV RNA level are independent factors significantly associated with high HOMA-IR in multivariate logistic analyses. Conclusions Chronic HCV infection was associated with metabolic characteristics including IR and lipid profile. IR was also associated with virological characteristics.
- Subjects
HEPATITIS C; DIABETES; LIPIDS; INSULIN resistance; BLOOD sugar; ALANINE aminotransferase
- Publication
Journal of Gastroenterology & Hepatology, 2015, Vol 30, Issue 5, p879
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/jgh.12313