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- Title
Changes of HBsAg and HBV DNA levels in Chinese chronic hepatitis B patients after 5 years of entecavir treatment.
- Authors
Seto, Wai‐Kay; Lam, Yuk‐Fai; Fung, James; Wong, Danny Ka‐Ho; Huang, Fung‐Yu; Hung, Ivan Fan‐Ngai; Lai, Ching‐Lung; Yuen, Man‐Fung
- Abstract
Background and Aim Hepatitis B surface antigen ( HBsAg) kinetics during long-term entecavir therapy has not been well investigated. Methods We described the cumulative serologic, virologic, and biochemical outcomes and the occurrence of signature entecavir mutations among 222 Chinese treatment-naïve chronic hepatitis B ( CHB) patients receiving entecavir for up to 5 years. Results The median rate of HBsAg reduction over 5 years was 0.125 log IU/mL/year. Patients with high baseline HBV DNA levels (≥ 8 log copies/mL or ≥ 7.3 log IU/mL), when compared with those with baseline hepatitis B virus ( HBV) DNA < 7.3 log IU/mL, had a significantly greater median rate of HBsAg reduction (0.178 and 0.102 log IU/mL/year, respectively, P < 0.001). The difference in HBsAg decline was most prominent in the first year (0.324 and 0.062 log IU/mL/year, respectively, P < 0.001). Greater median rates of HBsAg reduction were also found in hepatitis B e antigen ( HBeAg)-positive patients when compared with HBeAg-negative patients (0.144 and 0.098 log IU/mL/year, P = 0.015), and in patients with high baseline HBsAg levels (≥ 3 log IU/mL), when compared with patients with low baseline HBsAg < 3 log IU/mL (0.131 and 0.045 log IU/mL/year, respectively, P = 0.001). The 5-year cumulative rate of HBV DNA undetectability (< 20 IU/mL) was 97.1%. There were two cases of entecavir resistance, resulting in a 5-year cumulative resistance rate of 1.2%. Conclusion In contrast to the profound HBV DNA suppression, long-term entecavir treatment achieved only a slow decline in serum HBsAg. Although certain patient subgroups exhibit a more rapid HBsAg reduction, additional therapeutic agents are needed to increase the chance of HBsAg seroclearance in CHB.
- Subjects
CHRONIC hepatitis B; CELL surface antigens; DNA; GENETIC mutation; LIVER diseases
- Publication
Journal of Gastroenterology & Hepatology, 2014, Vol 29, Issue 5, p1028
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/jgh.12476