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- Title
Review Mechanisms of nitrate tolerance: potential roles of folate.
- Authors
Bellisarii, F. Iachini; Gallina, S.; Zimarino, M.; De Caterina, R.
- Abstract
More than 100 years since their introduction in cardiovascular therapy, nitrates continue to be widely used in ischaemic heart disease despite incomplete knowledge of their intimate mechanism of action. Particularly, the development of a progressive attenuation of their efficacy over prolonged use (tolerance) continues to be the subject of current investigation. Newer findings point to the role of increased intracellular oxidative stress as a mechanism for tolerance and to folic acid derivatives as pharmacologic means to attenuate its development. This paper reviews nitrate mechanism of action, the history of nitrate tolerance and newer findings related to the use of folate to prevent this phenomenon.
- Subjects
NITRATES; CORONARY disease; DRUG efficacy; FOLIC acid; THERAPEUTICS; OXIDATIVE stress; TOLERATION
- Publication
European Journal of Clinical Investigation, 2003, Vol 33, Issue 11, p933
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1046/j.1365-2362.2003.01239.x