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- Title
Intracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception.
- Authors
Tan, Huixin; Zeng, Xiaoyu; Ni, Jun; Liang, Kun; Xu, Cuiping; Zhang, Yanyang; Wang, Jiaxin; Li, Zizhou; Yang, Jiaxin; Han, Chunlei; Gao, Yuan; Yu, Xinguang; Han, Shihui; Meng, Fangang; Ma, Yina
- Abstract
Empathy enables understanding and sharing of others' feelings. Human neuroimaging studies have identified critical brain regions supporting empathy for pain, including the anterior insula (AI), anterior cingulate (ACC), amygdala, and inferior frontal gyrus (IFG). However, to date, the precise spatio-temporal profiles of empathic neural responses and inter-regional communications remain elusive. Here, using intracranial electroencephalography, we investigated electrophysiological signatures of vicarious pain perception. Others' pain perception induced early increases in high-gamma activity in IFG, beta power increases in ACC, but decreased beta power in AI and amygdala. Vicarious pain perception also altered the beta-band-coordinated coupling between ACC, AI, and amygdala, as well as increased modulation of IFG high-gamma amplitudes by beta phases of amygdala/AI/ACC. We identified a necessary combination of neural features for decoding vicarious pain perception. These spatio-temporally specific regional activities and inter-regional interactions within the empathy network suggest a neurodynamic model of human pain empathy. The neural underpinnings of empathy in response to the pain of others remains poorly understood. Here the authors reveal spatio-temporally specific activities and inter-regional interactions in the empathy network, suggesting a neurodynamic model of human pain empathy.
- Subjects
PAIN perception; PREFRONTAL cortex; CINGULATE cortex; ELECTROENCEPHALOGRAPHY; RISK perception; EMPATHY
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-49541-1