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- Title
Immunohistochemical and Mutational Analysis of c-kit in Gastrointestinal Neuroendocrine Cell Carcinoma.
- Authors
Ishikubo, Tsutomu; Akagi, Kiwamu; Kurosumi, Masafumi; Yamaguchi, Kensei; Fujimoto, Takahiro; Sakamoto, Hirohiko; Tanaka, Yoichi; Ochiai, Atsushi
- Abstract
Background: Gastrointestinal neuroendocrine cell carcinoma (NEC) is a highly aggressive tumor with poor prognosis, for which an effective therapy is highly desirable. Recently, use of a c-kit inhibitor achieved excellent results against gastrointestinal stromal tumor (GIST) that showed c-kit overexpression and mutation in most cases. According to recent studies, 17–44% of pulmonary NEC also expressed c-kit and the antitumor effect of c-kit inhibitor was demonstrated in vitro against small cell carcinoma of the lung. As gastrointestinal NECs are clinicopathologically similar to pulmonary NECs, we investigated c-kit expression and mutation in gastrointestinal NEC.
- Publication
Japanese Journal of Clinical Oncology, 2006, Vol 36, Issue 8, p494
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyl061