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- Title
The relationship of resting-state functional connectivity associated with prospective memory to CSF amyloid levels in the pre-dementia Alzheimer's disease continuum.
- Authors
Öztürk, Gülcan; Harı, Emre; Bayram, Ali; Demiralp, Tamer; Gürvit, İbrahim Hakan
- Abstract
Objective: It was aimed to examine the relationship between resting state functional connectivity (rsFC) and CSF amyloidbeta42 (Aβ42) levels related to prospective memory skills in people with pre-dementia Alzheimer's disease continuum. Low CSF Aβ42 level is associated with amyloid deposition in the brain and is suggested as an early biomarker of Alzheimer's disease. Methods: Sixty subjects with pre-dementia Alzheimer's disease continuum participated in the study. The Memory for Intentions Screening Test (MIST, Raskin 2009) was used to assess prospective memory. fMRI was used to obtain connectivity data. Using the participants' MIST total prospective memory scores as a regressor, rsFC was analyzed with Network Based Statistics (NBS). After the analysis, clustering was carried out with K-Means technique for 60 participants by using the inter-seed connectivity which was found to be significant. The resulting groups were compared in terms of connectivity values, prospective memory and other neuropsychological evaluation scores, CSF Aβ42 levels. The relationship between connectivity values and CSF Aβ42 levels was examined by correlation analysis. Data from a total of 22 participants were used in the analysis of CSF data. Results: In the between group comparison, the high connectivity group performed better on prospective memory and some neuropsychological measures. Besides, the high connectivity group had a higher education level (t=2.177, p=0.03) and a lower mean Aβ42 value (t=-2.864, p=0.01), that is, this group had more amyloid accumulation in the brain. A negative correlation was observed between Aβ42 levels and connectivity values (r=-0.541, p=0.009), that is, connectivity increases as amyloid accumulation increases. Conclusion: The fact that amyloid deposition was higher in the high connectivity group and cognitive performance and education level of this group were higher suggest a compensatory mechanism against the deteriorating effect of amyloid deposition. Another explanation is that amyloid deposition may occur as a result of high neural activity or connectivity. In both cases, reporting of subjective cognitive decline reveals a hidden risk of progression to dementia, although higher connectivity and accompanying better cognition are demonstrated crosssectionally.
- Subjects
PROSPECTIVE memory; ALZHEIMER'S disease; CEREBROSPINAL fluid; FUNCTIONAL connectivity; NEUROFIBRILLARY tangles; CEREBROSPINAL fluid examination; AMYLOID; NEUROPSYCHOLOGICAL tests
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2022, Vol 16, p234
- ISSN
1307-8798
- Publication type
Article
- DOI
10.2399/ana.22.003s