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- Title
UČESTALOST I VRSTA OBOLJENJA ŠTITNE ŽLIJEZDE KOD OBOLJELIH OD DIJABETES MELITUSA TIPA 2.
- Authors
Jandrić-Kočič, Marijana C.
- Abstract
Introduction: Numerous preclinical, molecular, and clinical studies indicate a causal association between type 2 diabetes mellitus (T2DM) and thyroid disorders. The presence of diabetes triggers a cascading, antichomeostatic reaction that results in thyroid disease. Pre-existing thyroid disease further impairs metabolic control and beta-cell function of diabetics. Objective: To determine the presence of statistically significant more frequent presence of hypothyroidism, thyroid nodules and welldifferentiated thyroid cancers in patients with verified T2DM compared to the rest of the population. To examine the existence of statistically significant correlation of hemoglobin A1c (HbA1C) values with the indicated thyroid diseases in patients with T2DM. Material and Methods: The study was performed as a cross-sectional study at the Krupa Health Center at the Uni from 01.09.2017. to 03/01/2018. The sample consisted of 186 patients, that is, two groups of 93 patients each. The first included patients diagnosed with T2DM for a minimum of 5 years without verified thyroiddisorder. The control group consisted of patients without thyroid disorder and type 2 diabetes mellitus present. Data were collected on the basis of history, physical examination, available medical records, laboratory analyzes and ultrasound examination. Data processing was performed using standard statistical methods. Results: The group of patients with verified T2DM had a statistically significant more frequent presence of hypothyroidism and thyroid nodules than the control group (p <0.05). For well-differentiated carcinomas, the difference was nonsignificant (p = 0.15). In the group of subjects diagnosed with T2DM, hypothyroidism and ultrasoundverified thyroid noduses, statistically significantly higher HbA1c was found compared to patients with T2DM without present thyroid diseases (p <0.05).Conclusion: The study confirmed that type 2 diabetes mellitus is a significant risk factor for hypothyroidism and thyroid nodules but not well-differentiated thyroid cancers. These diseases generally occur in patients with poor glycemic control (high HbA1c).
- Publication
Timocki Medicinski Glasnik, 2019, Vol 44, Issue 3, p109
- ISSN
0350-2899
- Publication type
Article