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- Title
Specific IgE Response and Omalizumab Responsiveness in Severe Allergic Asthma.
- Authors
Tajiri, Tomoko; Suzuki, Motohiko; Kutsuna, Takeo; Nishiyama, Hirono; Ito, Keima; Takeda, Norihisa; Fukumitsu, Kensuke; Kanemitsu, Yoshihiro; Fukuda, Satoshi; Umemura, Takehiro; Ohkubo, Hirotsugu; Maeno, Ken; Ito, Yutaka; Oguri, Tetsuya; Takemura, Masaya; Yoshikawa, Kosho; Niimi, Akio
- Abstract
aimed to assess whether the pretreatment specific IgE response could be a predictor of responsiveness to omalizumab in severe allergic asthma sensitized to perennial allergens. Methods: In this retrospective study, 41 adult patients with severe allergic asthma sensitized to perennial allergens (27 females; mean age 59 years) who had completed 52-week omalizumab treatment were enrolled. The Global Evaluation of Treatment Effectiveness was performed, and demographic characteristics and the positive ratios of specific IgE responses classified into five subgroups (pollen, dust mite, house dust, mold, and animal dander) were compared between responders and non-responders. Multivariate logistic regression analyses were performed to identify predictors of responsiveness to omalizumab. Results: Thirty-one patients (76%) were identified as responders. The number of sensitized aeroallergen subgroups and sensitization to pollens were significantly higher in responders than in non-responders (both p< 0.05). Multivariate logistic regression analysis showed that sensitization to pollen (OR = 8.41, p = 0.02) was independently associated with the effectiveness of omalizumab. Conclusion: Pretreatment serum pollen-specific IgE could be a predictor of responsiveness to omalizumab.
- Subjects
IMMUNOGLOBULIN E; OMALIZUMAB; ATOPY; ASTHMA; DEMOGRAPHIC characteristics
- Publication
Journal of Asthma & Allergy, 2023, Vol 16, p149
- ISSN
1178-6965
- Publication type
Article
- DOI
10.2147/JAA.S393683