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A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 9, p. 1429, doi. 10.1002/psp4.13202
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- Publication type:
- Article
Combining data on the bioavailability of midazolam and physiologically‐based pharmacokinetic modeling to investigate intestinal CYP3A4 ontogeny.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 9, p. 1570, doi. 10.1002/psp4.13192
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- Publication type:
- Article
Physiologically Based Pharmacokinetics Modeling in the Neonatal Population—Current Advances, Challenges, and Opportunities.
- Published in:
- Pharmaceutics, 2023, v. 15, n. 11, p. 2579, doi. 10.3390/pharmaceutics15112579
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- Publication type:
- Article
Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study.
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- Pharmaceutics, 2023, v. 15, n. 7, p. 1922, doi. 10.3390/pharmaceutics15071922
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- Publication type:
- Article
Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test.
- Published in:
- 2020
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- Publication type:
- journal article
Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory.
- Published in:
- Pharmaceutical Research, 2018, v. 35, n. 11, p. 1, doi. 10.1007/s11095-018-2487-1
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- Publication type:
- Article
Development and testing in healthy adults of oral hydrocortisone granules with taste masking for the treatment of neonates and infants with adrenal insufficiency.
- Published in:
- 2015
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- Publication type:
- Journal Article
Prediction of liver volume - a population-based approach to meta-analysis of paediatric, adult and geriatric populations - an update.
- Published in:
- Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 4, p. 290, doi. 10.1002/bdd.2063
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- Publication type:
- Article
Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults.
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- Biopharmaceutics & Drug Disposition, 2015, v. 36, n. 4, p. 245, doi. 10.1002/bdd.1937
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- Publication type:
- Article
Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents.
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- Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 6, p. 341, doi. 10.1002/bdd.1899
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- Publication type:
- Article
Development and Application of a Physiologically-Based Pharmacokinetic Model to Predict the Pharmacokinetics of Therapeutic Proteins from Full-term Neonates to Adolescents.
- Published in:
- AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00460-1
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- Publication type:
- Article
Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model.
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- AAPS Journal, 2014, v. 16, n. 3, p. 568, doi. 10.1208/s12248-014-9592-9
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- Publication type:
- Article
Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice.
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- Pediatric Anesthesia, 2011, v. 21, n. 3, p. 291, doi. 10.1111/j.1460-9592.2010.03323.x
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- Publication type:
- Article
Use of a physiologically based pharmacokinetic–pharmacodynamic model for initial dose prediction and escalation during a paediatric clinical trial.
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- British Journal of Clinical Pharmacology, 2021, v. 87, n. 3, p. 1378, doi. 10.1111/bcp.14528
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- Publication type:
- Article
Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children.
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- British Journal of Clinical Pharmacology, 2019, v. 85, n. 1, p. 100, doi. 10.1111/bcp.13764
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- Publication type:
- Article
Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.
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- British Journal of Clinical Pharmacology, 2016, v. 81, n. 5, p. 989, doi. 10.1111/bcp.12878
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- Publication type:
- Article
A pregnancy physiologically based pharmacokinetic (p- PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4.
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- British Journal of Clinical Pharmacology, 2012, v. 74, n. 5, p. 873, doi. 10.1111/j.1365-2125.2012.04363.x
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- Publication type:
- Article
Assessing the efficiency of mixed effects modelling in quantifying metabolism based drug-drug interactions: using in vitro data as an aid to assess study power.
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- Pharmaceutical Statistics, 2009, v. 8, n. 3, p. 186, doi. 10.1002/pst.373
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- Publication type:
- Article
Teicoplanin physiologically based pharmacokinetic modeling offers a quantitative assessment of a theoretical influence of serum albumin and renal function on its disposition.
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- European Journal of Clinical Pharmacology, 2021, v. 77, n. 8, p. 1157, doi. 10.1007/s00228-021-03098-w
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- Publication type:
- Article
Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis.
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- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 6, p. 1264, doi. 10.1002/cpt.3032
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- Publication type:
- Article
Another Step Toward Qualification of Pediatric Physiologically Based Pharmacokinetic Models to Facilitate Inclusivity and Diversity in Pediatric Clinical Studies.
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- Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 3, p. 735, doi. 10.1002/cpt.2777
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- Publication type:
- Article
Physiologically‐Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome.
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- Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 2, p. 496, doi. 10.1002/cpt.2458
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- Publication type:
- Article
Chloroquine Dosing Recommendations for Pediatric COVID‐19 Supported by Modeling and Simulation.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 2, p. 248, doi. 10.1002/cpt.1864
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- Publication type:
- Article
Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 1, p. 188, doi. 10.1002/cpt.905
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- Publication type:
- Article
Different pharmacokinetics of tramadol in mothers treated for labour pain and in their neonates.
- Published in:
- 2005
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- Publication type:
- Letter
Development and application of a pediatric mechanistic kidney model.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 7, p. 854, doi. 10.1002/psp4.12798
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- Publication type:
- Article
Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 3, p. 373, doi. 10.1002/psp4.12764
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- Publication type:
- Article
A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development.
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- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 9, p. 967, doi. 10.1002/psp4.12678
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- Publication type:
- Article
A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 5, p. 273, doi. 10.1002/psp4.12392
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- Publication type:
- Article
PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 7, p. 464, doi. 10.1002/psp4.12306
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- Publication type:
- Article
Using a Vancomycin PBPK Model in Special Populations to Elucidate Case‐Based Clinical PK Observations.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 4, p. 237, doi. 10.1002/psp4.12279
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- Publication type:
- Article
Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 3, p. 175, doi. 10.1002/psp4.12273
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- Publication type:
- Article
Modelling approaches to dose estimation in children.
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- British Journal of Clinical Pharmacology, 2005, v. 59, n. 6, p. 663, doi. 10.1111/j.1365-2125.2005.02429.x
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- Publication type:
- Article
An indirect response model of homocysteine suppression by betaine: optimising the dosage regimen of betaine in homocystinuria.
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- British Journal of Clinical Pharmacology, 2002, v. 54, n. 2, p. 140, doi. 10.1046/j.1365-2125.2002.01620.x
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- Publication type:
- Article
Complementary therapies for pharmacists.
- Published in:
- 2002
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- Publication type:
- Book Review
Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis.
- Published in:
- British Journal of Clinical Pharmacology, 2001, v. 51, n. 5, p. 451, doi. 10.1046/j.1365-2125.2001.01370.x
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- Publication type:
- Article
Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling.
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- 2012
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- Publication type:
- journal article
Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy.
- Published in:
- Clinical Pharmacokinetics, 2012, v. 51, n. 6, p. 365, doi. 10.2165/11597440-000000000-00000
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- Publication type:
- Article
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
- Published in:
- 2011
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- Publication type:
- journal article
Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients.
- Published in:
- Clinical Pharmacokinetics, 2011, v. 50, n. 12, p. 809, doi. 10.2165/11594420-000000000-00000
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- Publication type:
- Article
A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance.
- Published in:
- Clinical Pharmacokinetics, 2010, v. 49, n. 3, p. 189, doi. 10.2165/11318160-000000000-00000
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- Publication type:
- Article
Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children.
- Published in:
- 2006
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- Publication type:
- journal article
Forecasting Fetal Buprenorphine Exposure through Maternal–Fetal Physiologically Based Pharmacokinetic Modeling.
- Published in:
- Pharmaceutics, 2024, v. 16, n. 3, p. 375, doi. 10.3390/pharmaceutics16030375
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- Publication type:
- Article
Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: Which measure of variability should be used?
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- Journal of Clinical Pharmacology, 2014, v. 54, n. 3, p. 311, doi. 10.1002/jcph.206
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- Publication type:
- Article
Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions.
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- Journal of Clinical Pharmacology, 2013, v. 53, n. 8, p. 857, doi. 10.1002/jcph.100
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- Publication type:
- Article
Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.
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- Journal of Clinical Pharmacology, 2013, v. 53, n. 5, p. 559, doi. 10.1002/jcph.13
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- Publication type:
- Article
Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.
- Published in:
- Journal of Clinical Pharmacology, 2013, v. 53, n. 4, p. 456, doi. 10.1002/jcph.13
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- Publication type:
- Article
Authors' Reply to Völler et al: "Comment on: Preterm Physiologically Based Pharmacokinetic Model, Part I and Part II".
- Published in:
- 2021
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- Publication type:
- Letter
Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population.
- Published in:
- 2020
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- Publication type:
- journal article
Fetal Physiologically Based Pharmacokinetic Models: Systems Information on Fetal Blood Components and Binding Proteins.
- Published in:
- 2020
- By:
- Publication type:
- journal article