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- Title
Familial Papillary Thyroid Carcinoma: A Retrospective Analysis.
- Authors
McDonald, Thomas J.; Driedger, Albert A.; Garcia, Bertha M.; Van Uum, Stanislaus H. M.; Rachinsky, Irina; Chevendra, Vijaya; Breadner, Daniel; Feinn, Richard; Walsh, Stephen J.; Malchoff, Carl D.
- Abstract
Background. Whether or not the familial form of papillary thyroid carcinoma is more aggressive than the sporadic form of the disease remains controversial. Methods. To explore this question and whether or not increased aggressiveness is more apparent in families with multiple affected members, we performed a chi square by trend analysis on our patients clinical and pathologic data comparing: first degree families with three or more affected members versus first degree families with two affected members versus sporadic cases of papillary thyroid carcinoma. Results. No statistically significant trends were seen for any presenting surgical pathology parameter, age at presentation, length of follow-up or gender distribution. The familial groups exhibited significant trends for higher rates of reoperation (P = 0.05) and/or requiring additional radioactive iodine therapy (P = 0.03), distant metastases (P = 0.003) and deaths (P = 0.01). These aggressive features were most apparent in certain families with three or more affected members. Conclusions. Using the chi square by trend analysis, a significant trend was seen for the familial form of papillary thyroid cancer to possess more aggressive features than the sporadic disease. Prompt recognition of the familial nature of the disease may provide earlier diagnosis and treatment in similarly affected family members.
- Subjects
CLINICAL trials; THYROID cancer; PAPILLARY carcinoma; TREND analysis; SURGICAL pathology
- Publication
Journal of Oncology, 2011, p1
- ISSN
1687-8450
- Publication type
Article
- DOI
10.1155/2011/948786