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- Title
Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line.
- Authors
Žižić, Jovana B; Vuković, Nenad L; Jadranin, Milka B; Anđelković, Boban D; Tešević, Vele V; Kacaniova, Miroslava M; Sukdolak, Slobodan B; Marković, Snežana D
- Abstract
BACKGROUND Propolis is a complex resinous sticky substance that honeybees collect from buds and exudates of various plants. Owing to its versatile biological and pharmacological activities, propolis is widely used in medicines, cosmetics and foods. The aim of this study was to evaluate the cytotoxic and antioxidative effects of various ethanolic extracts of propolis ( EEPs) on human colon cancer cell line HCT-116 and compare them with their composition determined by HPLC-DAD. RESULTS The most abundant flavonoids in all samples were chrysin, pinocembrin and galangin (12.697-40.811 µg mg−1), while the main phenolic acids were caffeic acid, ferulic acid and isoferulic acid. Dose- and time-dependent inhibition of growth of HCT-116 cells was observed for all propolis samples, with IC50 values ranging from 26.33 to 143.09 µg mL−1. Differences in cytotoxic activity of propolis samples were associated with differences in their composition. All EEP samples reduced both superoxide anion radical and nitrite levels and also had strong DPPH-scavenging activity. CONCLUSION All tested propolis samples had pronounced cytotoxic and antioxidative activities. © 2013 Society of Chemical Industry
- Subjects
HONEYBEES; PROPOLIS; ANTIOXIDANTS; ANTINEOPLASTIC antibiotics; CELL lines; COLON cancer; THERAPEUTICS
- Publication
Journal of the Science of Food & Agriculture, 2013, Vol 93, Issue 12, p3001
- ISSN
0022-5142
- Publication type
Article
- DOI
10.1002/jsfa.6132