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- Title
Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides.
- Authors
Ioannou, Maria; Sourli, Fani; Mylonis, Ilias; Barbanis, Sotirios; Papamichali, Rodula; Kouvaras, Evangelos; Zafiriou, Efterpi; Siomou, Paraskevi; Klimi, Eleni; Simos, George; Roussaki-Schulze, Aggeliki-Victoria; Koukoulis, George
- Abstract
Background: Expression of hypoxia inducible factor 1 (HIF-1) alpha can be linked to inflammation through reciprocal interactions with several cytokines. This finding is in accordance with the previously noted HIF-1 alpha overexpression in psoriatic lesional keratinocytes. Methods: In this study we have employed a carefully selected panel of antibodies and quantitative morphometric analysis to compare HIF-1 alpha immunoreactivity in psoriatic biopsy samples vs. that in samples obtained from psoriasiform dermatitides. Results: We found statistically significant HIF-1 alpha overexpression in psoriasis. Furthermore, we observed a previously unreported preferential localization of immunoreactive keratinocytes in the immediate vicinity of inflamed and elongated papillae. This pattern of immunoreactivity may partially account for the observed increase of HIF-1 alpha immunostaining in psoriasis. Conclusions: Overall, our findings imply that possible novel therapeutic intervention(s) on the HIF-1 alpha pathway may offer another approach in controlling the inflammatory activity of psoriatic lesions.
- Subjects
HYPOXEMIA; PSORIASIS; SKIN inflammation; CYTOKINES; KERATINOCYTES; BIOPSY; IMMUNOREGULATION
- Publication
Journal of Cutaneous Pathology, 2009, Vol 36, Issue 12, p1255
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.2009.01264.x