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- Title
Expression of syndecan-1 is a sensitive marker for cutaneous plasmacytoma.
- Authors
Bayer-Garner, Ilene B.; Joseph, Lija; Sanderson, Ralph D.; Smoller, Bruce R.
- Abstract
Background: Cutaneous plasmacytoma is a well-recognized, yet infrequent, occurrence in multiple myeloma (MM). There are limitations in the morphologic assessment, and as such, the diagnosis presents some difficulty, particularly with the plasmablastic type. Methods: Pathology reports of 2357 patients with a diagnosis of MM were reviewed. Twenty patients yielded a total of 25 plasmacytomas, 10 of which were analyzed for syndecan-1 immunoreactivity. Bartl grade of bone marrow and cutaneous plasmacytoma was compared and immunoglobulin secretory status of the patients was assessed. Results: The incidence of cutaneous plasmacytoma was found to be 1 in 118 patients with MM. Immunoglobulin secretion was found to be predominantly IgG. There was a trend for the plasmacytoma Bartl grade to be equal to or greater than that of the corresponding bone marrow Bartl grade, suggesting a more aggressive phenotype in the metastatic lesion. Conclusion: Syndecan-1 was found to be a sensitive marker for plasmacytomas, independent of cytologic differentiation.
- Subjects
MULTIPLE myeloma; PLASMACYTOMA; IMMUNOGLOBULIN G; TUMOR markers
- Publication
Journal of Cutaneous Pathology, 2003, Vol 30, Issue 1, p18
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1034/j.1600-0560.2003.300103.x