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- Title
Prospectively Randomized Trial Using Perioperative Low-dose Octreotide to Prevent Organ-related and General Complications after Pancreatic Surgery and Pancreatico-jejunostomy.
- Authors
Hesse, Uwe J.; DeDecker, Christophe; Houtmeyers, Phillipe; Demetter, Pieter; Ceelen, Wim; Pattyn, Piet; Troisi, Roberto; deHemptinne, Bernard
- Abstract
The aim of the present study was to evaluate the influence of low-dose perioperative octreotide on the prevention of complications pancreatic surgery and general complications) in patients undergoing pancreatic surgery followed by pancreaticojejunostomy. A total of 105 patients were randomized to receive either octreotide 0.1 mg subcutaneously 3 times/day for a total of 7 days or no octreotide. The primary endpoints were the occurence of a pancreatic fistula and or general complications, including extended length of hospital stay. There were 25 surgical draining procedures performed and 80 duodenopancreatectomics with or without preservation of the pylorus. In all, 25 (23.8%) of the patients were treated for chronic pancreatitis, 8 (7.6%) for benign tumoral disease, and 72 (68.6%) for carcinoma. All patients underwent pancreuticojejunostomy.
- Subjects
OPERATING room nursing; SURGICAL nursing; OCTREOTIDE acetate; ANTINEOPLASTIC agents; GASTROINTESTINAL agents; PANCREATICODUODENECTOMY; PANCREATECTOMY; PANCREATIC surgery
- Publication
World Journal of Surgery, 2005, Vol 29, Issue 10, p1325
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-005-7546-1